Increased Bile Acid Biosynthesis Is Associated With Irritable Bowel Syndrome With Diarrhea Banny S. Wong, Michael Camilleri, Paula Carlson, Sanna McKinzie,

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Increased Bile Acid Biosynthesis Is Associated With Irritable Bowel Syndrome With Diarrhea Banny S. Wong, Michael Camilleri, Paula Carlson, Sanna McKinzie, Irene Busciglio, Olga Bondar, Roy B. Dyer, Jesse Lamsam, Alan R. Zinsmeister Clinical Gastroenterology and Hepatology Volume 10, Issue 9, Pages 1009-1015.e3 (September 2012) DOI: 10.1016/j.cgh.2012.05.006 Copyright © 2012 AGA Institute Terms and Conditions

Figure 1 (A) Association of fasting serum C4 and subgroup. There was a significant overall univariate association with group and a significant difference between IBS-D and both HV and IBS-C groups. (B) Association of fasting serum C4 and serum FGF19; note the significant negative association, based on Spearman correlation. Inset, the same data are plotted based on rank transformation, and the line demonstrates the inverse correlation between serum FGF19 and C4. Clinical Gastroenterology and Hepatology 2012 10, 1009-1015.e3DOI: (10.1016/j.cgh.2012.05.006) Copyright © 2012 AGA Institute Terms and Conditions

Figure 2 Association of total 48-hour stool BA and subgroup. There was a borderline overall univariate association with group and a significant difference between IBS-D and IBS-C groups. Clinical Gastroenterology and Hepatology 2012 10, 1009-1015.e3DOI: (10.1016/j.cgh.2012.05.006) Copyright © 2012 AGA Institute Terms and Conditions

Figure 3 Relationship between fasting serum C4 and total 48-hour stool BA excretion (A) and total 48-hour stool weight (B). Clinical Gastroenterology and Hepatology 2012 10, 1009-1015.e3DOI: (10.1016/j.cgh.2012.05.006) Copyright © 2012 AGA Institute Terms and Conditions

Figure 4 Relationship between total 48-hour stool weight (A) and stool fat (B) and total 48-hour stool BA excretion. Clinical Gastroenterology and Hepatology 2012 10, 1009-1015.e3DOI: (10.1016/j.cgh.2012.05.006) Copyright © 2012 AGA Institute Terms and Conditions

Figure 5 Relationship between BMI and total stool BA excretion. Clinical Gastroenterology and Hepatology 2012 10, 1009-1015.e3DOI: (10.1016/j.cgh.2012.05.006) Copyright © 2012 AGA Institute Terms and Conditions

Supplementary Figure 1 The 3 SNPS in FGFR4 were not in linkage disequilibrium. Clinical Gastroenterology and Hepatology 2012 10, 1009-1015.e3DOI: (10.1016/j.cgh.2012.05.006) Copyright © 2012 AGA Institute Terms and Conditions