Chromatin replication: Finding the right connection

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Chromatin replication: Finding the right connection Torsten Krude  Current Biology  Volume 9, Issue 11, Pages R394-R396 (June 1999) DOI: 10.1016/S0960-9822(99)80251-6

Figure 1 An illustration of how PCNA may target CAF-1 to replicated DNA. The deposition of the PCNA ring (red) onto replicating DNA by RFC (orange) provides a marker of replicated DNA for a recruitment of the chromatin assembly complex, consisting of CAF-1 (green) and newly synthesised histones (blue squares). Following assembly of a nucleosome (blue cylinder), CAF-1 and PCNA–RFC dissociate from the DNA again. For simplification, other components of the replication fork, its topography and the possible involvement of parental chromatin structures are omitted from this scheme (for more details see [1,5,7]. Current Biology 1999 9, R394-R396DOI: (10.1016/S0960-9822(99)80251-6)