IQ Deficits Linked with an Increase in Blood Lead from 10 g/dl to 20 g/dl.

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Presentation transcript:

IQ Deficits Linked with an Increase in Blood Lead from 10 g/dl to 20 g/dl

Percent of Preschool Children Exceeding Selected Blood Lead Levels, NHANES II - III

Blood Lead Levels > 10 µg/dL among Children in Rochester, 1995

Lead Toxicity at Blood Lead Levels <10 g/dl

IQ Scores for Tibial Bone Lead and Mean Lifetime Blood Lead Levels

Why not change the blood lead level of concern at this time?

Mean IQ Change per 1 g/dl at 5 years for Children with Peak Blood Lead < 10 g/dl (n=101)

Mean IQ Change per 1 g/dl at 5 years for Children with Peak Blood Lead < 10 g/dl (n=101)

Research Supporting Adverse Cognitive Effects at Blood Lead Levels < 10 µg/dL (through 2008)

Lead Reduces Neurite Length in Dopaminergic Neurons after 48 Hr Exposure to Lead Acetate

The Prevention Paradox

Dose Response Relationship of Maternal Blood Lead Levels and Birthweight

Gray Matter Loss by Childhood Lead Exposure

Key Imaging Findings in ADHD

Reduction in Gray Matter by Childhood Blood Lead Levels and Subject’s Sex

Adjusted Hazard Ratios for Blood Lead Levels and other Covariates, NHANES Mortality Study

Adjusted Hazard Ratios for Blood Lead Levels and other Covariates, NHANES Mortality Study

Risk Factors for Premature Deaths in US Adults NHANES Mortality Study

The Precipitous Decline in Hypertension in U. S The Precipitous Decline in Hypertension in U.S. Adults > 20 years, NHANES

Blood Lead Levels and Hypertension in U. S Blood Lead Levels and Hypertension in U.S. Adults > 20 years, NHANES

Blood Lead Levels and Public Health Policies in the United States, 1970-2010

The Global Elimination of Lead Poisoning