In vitro photoacoustic visualization of myocardial ablation lesions

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Presentation transcript:

In vitro photoacoustic visualization of myocardial ablation lesions Nicholas Dana, BSc, Luigi Di Biase, MD, PhD, FHRS, Andrea Natale, MD, FHRS, Stanislav Emelianov, PhD, Richard Bouchard, PhD Heart Rhythm Volume 11, Issue 1, Pages 150-157 (January 2014) DOI: 10.1016/j.hrthm.2013.09.071 Copyright © 2014 Heart Rhythm Society Terms and Conditions

Figure 1 Schematic of combined photoacoustic/ultrasound (PA/US) imaging system. Heart Rhythm 2014 11, 150-157DOI: (10.1016/j.hrthm.2013.09.071) Copyright © 2014 Heart Rhythm Society Terms and Conditions

Figure 2 A: Single-wavelength photoacoustic image (710 nm) overlaying ultrasound image with ablated and non-ablated ROIs. B: Mean ROI photoacoustic signal plotted vs wavelength. C: Tissue characterization map (TCM). D: Reference spectra for ablated (averaged over eight samples from two hearts) and non-ablated (derived from optical extinction data from deoxyhemoglobin) tissue. Heart Rhythm 2014 11, 150-157DOI: (10.1016/j.hrthm.2013.09.071) Copyright © 2014 Heart Rhythm Society Terms and Conditions

Figure 3 Top-view (A) and side-view (C) stained sample gross pathology with sample boundary (blue) and ablated region (red) segmentation. Matching top-view (B) and side-view (D) TCM-US images with segmented ablated region (red). Heart Rhythm 2014 11, 150-157DOI: (10.1016/j.hrthm.2013.09.071) Copyright © 2014 Heart Rhythm Society Terms and Conditions

Figure 4 Three-dimensional rendering (A) of TCM volume with clipping plane corresponding to tissue bisection (B). Matching top-view (C) and side-view (D) gross pathology photographs with axes and fields of view indicated by arrows and boxes, respectively. Heart Rhythm 2014 11, 150-157DOI: (10.1016/j.hrthm.2013.09.071) Copyright © 2014 Heart Rhythm Society Terms and Conditions