Molecular endoscopy for targeted imaging in the digestive tract

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Presentation transcript:

Molecular endoscopy for targeted imaging in the digestive tract Jeong Hoon Lee, MD, Prof Thomas D Wang, PhD The Lancet Gastroenterology & Hepatology Volume 1, Issue 2, Pages 147-155 (October 2016) DOI: 10.1016/S2468-1253(16)30027-9 Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 Optical properties of tissue Haemoglobin (Hb) and oxyhaemoglobin (HbO2) absorption dominates the visible spectrum, used by white light endoscopy (WLE), but has minimal effect in the near-infrared (NIR) range. AFI=autofluorescence imaging. NBI=narrow-band imaging. OCT=optimal coherence tomography. OFDI=optimal frequency domain imaging. FITC=fluorescein isothiocyanate. The Lancet Gastroenterology & Hepatology 2016 1, 147-155DOI: (10.1016/S2468-1253(16)30027-9) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 2 Detection of sessile serrated adenoma in proximal colon Image shows non-polypoid adenoma (arrow) on white light endoscopy (A), fluorescence (B), reflectance (C), and ratio (D) image. Ratio image shows lesion margins (red). Reproduced from Joshi et al (2016),40 by permission of Elsevier. The Lancet Gastroenterology & Hepatology 2016 1, 147-155DOI: (10.1016/S2468-1253(16)30027-9) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 3 Detection of tubular adenomas in colon using c-Met peptide Grossly visible polyp (red arrow) and non-polypoid adenoma (blue arrow) seen on white light endoscopy and near-infrared fluorescence. Reproduced from Burggraaf et al (2015),30 by permission of the Nature Publishing Group. The Lancet Gastroenterology & Hepatology 2016 1, 147-155DOI: (10.1016/S2468-1253(16)30027-9) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 4 Localisation of early neoplasia in Barrett's oesophagus High-grade dysplasia (HGD) and early oesophageal adenocarcinoma (OAC) seen on fluorescence with corresponding white light endoscopy images. Reproduced from Joshi et al (2016),36 by permission of Thieme Medical Publishers. BO=Barrett's oesophagus. GOJ=gastro-oesophageal junction. The Lancet Gastroenterology & Hepatology 2016 1, 147-155DOI: (10.1016/S2468-1253(16)30027-9) Copyright © 2016 Elsevier Ltd Terms and Conditions