Volume 124, Issue 4, Pages (April 2003)

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Volume 124, Issue 4, Pages 880-888 (April 2003) Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis Ralf Kiesslich, Johannes Fritsch, Martin Holtmann, Heinz H. Koehler, Manfred Stolte, Stephan Kanzler, Bernhard Nafe, Michael Jung, Peter R. Galle, Markus F. Neurath Gastroenterology Volume 124, Issue 4, Pages 880-888 (April 2003) DOI: 10.1053/gast.2003.50146 Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 1 Flow diagram of the progress through the phases of the actual randomized trial according to the CONSORT statement. Data from Moher et al.20. Gastroenterology 2003 124, 880-888DOI: (10.1053/gast.2003.50146) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 3 (A) Within previously unremarkable colonic mucosa, a discretely elevated lesion is visible after staining (arrows). (B) On closer inspection, an irregular surface structure is visible. On histologic analysis, this lesion was identified as low-grade intraepithelial neoplasia. Gastroenterology 2003 124, 880-888DOI: (10.1053/gast.2003.50146) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 4 (A) The native colonic mucosa shows areas of focal erythema. (B) After CE, a flat lesion is seen that correlates with high-grade intraepithelial neoplasia on histology. Gastroenterology 2003 124, 880-888DOI: (10.1053/gast.2003.50146) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 5 (A) Magnification endoscopy of a superficially spreading colon cancer in UC. (B) The respective histologic findings correlate well with the endoscopic picture. Gastroenterology 2003 124, 880-888DOI: (10.1053/gast.2003.50146) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 2 (A) Pseudopolyp shortly after vital staining with methylene blue. The surface staining pattern has the same structure as the surrounding mucosa (pit pattern I). (B) Staining pattern of a hyperplastic polyp after absorption of methylene blue. The crypts show a stellate distribution pattern (pit pattern II). In both cases, histologic analysis showed a hyperplastic epithelium without neoplastic changes. Gastroenterology 2003 124, 880-888DOI: (10.1053/gast.2003.50146) Copyright © 2003 American Gastroenterological Association Terms and Conditions