Fas NF-κB JNK Bcl-2 Akt p21 Bax Ras TRAILR p53 EGFR TRADD Myc TNFR Receptor that recognizes and transmits apoptotic signals R -4 NF-κB Transcription factor for survival genes T +5 JNK Transcription factor for apoptosis genes T -3 Bcl-2 Akt p21 Protein that relays apoptosis signals M -3 Bax Protein that promotes cell death P -2 Ras Protein that relays growth/ survival signals M +3 Protein that relays survival signals M +3 TRAILR Protein that promotes cell survival P +2 p53 Protein that stimulates transcription of apoptosis genes and activates apoptosis T/M/P -5 Receptor that recognizes and transmits apoptotic signals R -4 EGFR Receptor that transmits growth/survival signals. R +4 TRADD Protein that relays apoptosis signals in the cell M -2 Myc Transcription factor for growth/survival genes TNFR Receptor that recognizes and transmits survival signals Caspase Protein that promotes cell death Survivin Protein that promotes cell survival R +3 T +4 P -1 P +1

Fas NF-κB JNK Bcl-2 Akt p21 Bax Ras TRAILR p53 EGFR TRADD Myc TNFR Receptor that recognizes and transmits apoptotic signals R -4 NF-κB Transcription factor for survival genes T +5 JNK Transcription factor for apoptosis genes T -3 Bcl-2 Akt p21 Protein that relays apoptosis signals M -3 Bax Protein that promotes cell death P -2 Ras Protein that relays growth/ survival signals M +3 Protein that relays survival signals M +3 TRAILR Protein that promotes cell survival P +2 p53 Protein that stimulates transcription of apoptosis genes and activates apoptosis T/M/P -5 Receptor that recognizes and transmits apoptotic signals R -4 EGFR Receptor that recognizes and transmits growth/survival signals. R +4 TRADD Protein that relays apoptosis signals in the cell M -2 Myc Transcription factor for growth/survival genes TNFR Receptor that recognizes and transmits survival signals Caspase Protein that promotes cell death Survivin Protein that promotes cell survival R +3 T +4 P -1 P +1

FasL FasL TRAIL EGF FasL TRAIL EGF FasL TRAIL EGF TRAIL EGF TNF TNF Apoptosis signal protein S -1 TRAIL EGF Growth/ survival signal protein S +1 FasL Apoptosis signal protein S -1 TRAIL EGF Growth/ survival signal protein S +1 FasL Apoptosis signal protein S -1 TRAIL EGF Growth/ survival signal protein S +1 Apoptosis signal protein S -1 TRAIL EGF Growth/ survival signal protein S +1 TNF Growth/ survival signal protein TNF Growth/ survival signal protein TNF Growth/ survival signal protein TNF Growth/ survival signal protein S +1 S +1 S +1 S +1