Re: David J. McConkey, Woonyoung Choi, Colin P. N. Dinney Re: David J. McConkey, Woonyoung Choi, Colin P.N. Dinney. New Insights into Subtypes of Invasive Bladder Cancer: Considerations of the Clinician. Eur Urol 2014;66:609–10  Mattias Aine, Fredrik Liedberg, Gottfrid Sjödahl, Mattias Höglund  European Urology  Volume 67, Issue 4, Pages e73-e75 (April 2015) DOI: 10.1016/j.eururo.2014.08.063 Copyright © 2014 European Association of Urology Terms and Conditions

Fig. 1 The interrelationship between the Lund and MD Anderson (MDA) classification systems. (A) Clustered heat map visualization of the full Lund data set (n=308). Columns represent individual tumor samples and are grouped by taxonomy subtype. Rows correspond to the 500 most significant probes (seven-group analysis of variance [ANOVA]) that are differentially expressed across the full Lund data set. (B) Clustered heat map visualization of the full MDA data set (GSE48075), with tumor samples ordered by Lund subtypes and showing the same set of probes as in (A). (C) Visualization of the muscle-invasive urothelial bladder cancer subset of the Lund data (n=93) ordered by taxonomy subtype within each MDA subtype. Rows correspond to the top 500 most significant (three-group ANOVA) differentially expressed probes in the MDA discovery set (n=73). (D) The MDA discovery set visualized as in (C). (E) Diagrams showing the proportions of Lund and MDA subtype tumors in the respective data sets. In (A) and (B), as well as in (C) and (D), the figure widths are proportional to the number of tumors in the larger set. ANOVA=analysis of variance; MDA=MD Anderson Cancer Center; MI=muscle invasive; NMI=non–muscle invasive. European Urology 2015 67, e73-e75DOI: (10.1016/j.eururo.2014.08.063) Copyright © 2014 European Association of Urology Terms and Conditions