Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle

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Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle Matthew J. Schiewer, Karen E. Knudsen Cancer Cell Volume 31, Issue 4, Pages 471-473 (April 2017) DOI: 10.1016/j.ccell.2017.03.012 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Summary of Hydbring et al. Through several screens, it was determined that a subset of miRNAs target cyclins and CDKs, which are positive drivers of the cell cycle. These “cell-cycle-targeting miRNAs” were found to be inversely correlated with cyclins/CDKs in The Cancer Genome Atlas (TCGA) data, as well as either reduced or deleted in several tumor types. Therapeutic efficacy of these cell-cycle-targeting miRNAs was enriched in TNBC and gastric cancer cell lines, which was validated in chemotherapy-resistant PDX models. Cancer Cell 2017 31, 471-473DOI: (10.1016/j.ccell.2017.03.012) Copyright © 2017 Elsevier Inc. Terms and Conditions