Single-phase coronary artery CT angiography extracted from stress dynamic myocardial CT perfusion on third-generation dual-source CT: Validation by coronary.

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Single-phase coronary artery CT angiography extracted from stress dynamic myocardial CT perfusion on third-generation dual-source CT: Validation by coronary angiography Yan Yi, Wei Wu, Lu Lin, Hong-Zhi Zhang, Hao Qian, Zhu-Jun Shen, Yun Wang, Zheng-Yu Jin, Harold Litt, Yi-Ning Wang International Journal of Cardiology Volume 269, Pages 343-349 (October 2018) DOI: 10.1016/j.ijcard.2018.06.112 Copyright © 2018 The Authors Terms and Conditions

Fig. 1 Flowchart of subject enrolment and study design. Based on the predefined inclusion and exclusion criteria, 56 patients successfully underwent myocardial CTP and routine CCTA examination. The image quality and diagnostic performance were compared between CCTA from CTP and routine CCTA using on coronary angiography as the gold standard. CCTA = coronary CT angiography; ATP = adenosine triphosphate; CTP = CT perfusion. International Journal of Cardiology 2018 269, 343-349DOI: (10.1016/j.ijcard.2018.06.112) Copyright © 2018 The Authors Terms and Conditions

Fig. 2 Example case 1. A 67-year-old man with chest pain for 3 years underwent both routine coronary CT angiography (CCTA) and CT perfusion. Routine CCTA images (A) and single-phase CCTA images (B) both illustrate mixed plaque in the proximal segment of the left anterior descending branch and first diagonal (D1) (red arrows), with no significant difference in qualitative and quantitative quality. Stress dynamic CT perfusion (C) shows reduced perfusion in the anterior wall of left ventricle and inter-ventricular septum (black and white triangle). Coronary angiography (D) confirms the lesions showed by CCTA. International Journal of Cardiology 2018 269, 343-349DOI: (10.1016/j.ijcard.2018.06.112) Copyright © 2018 The Authors Terms and Conditions

Fig. 3 ROC results analysis between SP-CCTA and routine CCTA. Receiver-operating-characteristic (ROC) curves show the diagnostic performance comparison between SP-CCTA (solid line in blue) and routine CCTA (solid line in green). The area under the ROC curve for single phase-CCTA and routine CCTA were 0.851 (95% CI, 0.772 to 0.930) and 0.854 (95% CI, 0.776 to 0.932) for the diagnosis of stenosis of 50% or more on a per-vessel basis (A); 0.829 (95% CI, 0.741 to 0.917) and 0.843(95% CI, 0.758 to 0.927) for the diagnosis of stenosis of 70% or more on a per-vessel basis (B); 0.891 (95% CI, 0.841 to 0.942) and 0.911 (95% CI, 0.864 to 0.958) for the diagnosis of stenosis of 50% or more on a per-segment basis (C); 0.859 (95% CI, 0.782 to 0.937) and 0.878 (95% CI, 0.803 to 0.952) for the diagnosis of stenosis of 70% or more on a per-segment basis (D). SP-CCTA = single-phase CCTA; R-CCTA = routine CCTA, other abbreviations as in Fig. 1. International Journal of Cardiology 2018 269, 343-349DOI: (10.1016/j.ijcard.2018.06.112) Copyright © 2018 The Authors Terms and Conditions