Mucositis-Related Morbidity and Resource Utilization in Head and Neck Cancer Patients Receiving Radiation Therapy With or Without Chemotherapy Barbara.

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Presentation transcript:

Mucositis-Related Morbidity and Resource Utilization in Head and Neck Cancer Patients Receiving Radiation Therapy With or Without Chemotherapy Barbara A. Murphy, MD, Jennifer L. Beaumont, MS, John Isitt, MS, Adam S. Garden, MD, Clement K. Gwede, PhD, MPH, Andy M. Trotti, MD, Ruby F. Meredith, MD, Joel B. Epstein, DMD, MSD, Quynh-Thu Le, MD, David M. Brizel, MD, Lisa A. Bellm, MIM, Nancy Wells, DNSc, David Cella, PhD Journal of Pain and Symptom Management Volume 38, Issue 4, Pages 522-532 (October 2009) DOI: 10.1016/j.jpainsymman.2008.12.004 Copyright © 2009 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Maximum severity of mouth and throat soreness by type of radiation therapy. The rates of severe pain were not significantly different (P=0.175 by Fisher's exact test) with regard to radiation technique. Conventional RT=conventional RT±CB. Journal of Pain and Symptom Management 2009 38, 522-532DOI: (10.1016/j.jpainsymman.2008.12.004) Copyright © 2009 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 Opioid use. a) Route of administration. b) Severity of mouth and throat soreness over time, according to opioid use. The overall test for the effect of time was statistically significant (P<0.001 by general linear model). Changes in mouth and throat soreness at each time point compared with baseline were also statistically significant (P<0.001 by general linear model). c) Mean OMWQ-HN scores over time, according to opioid use. Scores among patients taking opioids were significantly greater than those among patients not taking opioids at Weeks 1–2 (P=0.025) and 3–4 (P=0.001), and were not significantly different at Weeks 5–6 (P=0.256). Journal of Pain and Symptom Management 2009 38, 522-532DOI: (10.1016/j.jpainsymman.2008.12.004) Copyright © 2009 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 3 Hospitalizations and their relationship with mucositis. Journal of Pain and Symptom Management 2009 38, 522-532DOI: (10.1016/j.jpainsymman.2008.12.004) Copyright © 2009 U.S. Cancer Pain Relief Committee Terms and Conditions