Oncogenic B-Raf mutations

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Oncogenic B-Raf mutations Amardeep S Dhillon, Walter Kolch Cancer Cell Volume 5, Issue 4, Pages 303-304 (April 2004) DOI: 10.1016/S1535-6108(04)00087-X

Figure 1 B-Raf activation by mutation A: B-Raf mutations cluster in the P loop and activation loop. These loops interact via a hydrophobic interface (shaded blue) including an important contact between F467 and V599. Activating phosphorylation on T598 and S601 is indicated. Mutations analyzed by Wan et al. are color coded (red, low activity; orange, medium activity; green, high activity). B: Low-activity B-Raf mutants stimulate ERK through Raf-1. Cancer Cell 2004 5, 303-304DOI: (10.1016/S1535-6108(04)00087-X)