Volume 143, Issue 2, Pages 287-293 (November 2016) Working together to shape the endometrial cancer research agenda: The top ten unanswered research questions  Y. Louise Wan, Rachel Beverley-Stevenson, Daloni Carlisle, Sinead Clarke, Richard J. Edmondson, Steve Glover, Julie Holland, Carol Hughes, Henry C. Kitchener, Sarah Kitson, Tracie Miles, Richard Morley, Jo Morrison, Linsey Nelson, Melanie Powell, Laura Sadler, Anne Tomlinson, Katharine Tylko-Hill, Jo Whitcombe, Emma J. Crosbie  Gynecologic Oncology  Volume 143, Issue 2, Pages 287-293 (November 2016) DOI: 10.1016/j.ygyno.2016.08.333 Copyright © 2016 The Authors Terms and Conditions

Fig. 1 Study flow diagram showing the number of participants and submissions at each stage. Gynecologic Oncology 2016 143, 287-293DOI: (10.1016/j.ygyno.2016.08.333) Copyright © 2016 The Authors Terms and Conditions

Fig. 2 Comparison of thematic analysis between responses from (A) lay and (B) professional participants. The submissions from the 413 respondents to the initial survey were thematically analysed. Where respondents had offered multiple suggestions these were analysed separately. Gynecologic Oncology 2016 143, 287-293DOI: (10.1016/j.ygyno.2016.08.333) Copyright © 2016 The Authors Terms and Conditions

Fig. 3 Distribution of evidence base for questions from each of 7 domains. Each of 247 unique questions was searched against current literature. The frequency with which questions from each domain were submitted and the proportion within each of these which had been addressed at each level of evidence (Level 1–5 - Oxford 2011 Levels of Evidence [17]) are shown. Those research questions where level 1 evidence was available were further subclassified into those where the conclusion showed that there was sufficient evidence i.e. ‘answered’ and those where the evidence was insufficient (i.e. level 1 alone) to state that further research was required. Gynecologic Oncology 2016 143, 287-293DOI: (10.1016/j.ygyno.2016.08.333) Copyright © 2016 The Authors Terms and Conditions

Fig. 4 Frequency of prioritisation of the top 30 questions in prioritisation survey according to background. The frequency with which each of the 30 questions was prioritised by participants as their top 2 most important in each domain is shown along with the relative proportion of each stakeholder group which made this selection. The responses of groups making up the lay participants are shown in shades of green whilst the responses from groups making up the professional participants are shaded blue. Those questions selected to constitute the final ten are indicated by the asterisks. Gynecologic Oncology 2016 143, 287-293DOI: (10.1016/j.ygyno.2016.08.333) Copyright © 2016 The Authors Terms and Conditions

Fig. 5 Final top ten unanswered research questions in EC. Gynecologic Oncology 2016 143, 287-293DOI: (10.1016/j.ygyno.2016.08.333) Copyright © 2016 The Authors Terms and Conditions