Figure 1 Immunofluorescence pattern of patient septin-5-immunoglobulin G binding to mouse tissues Immunofluorescence pattern of patient septin-5-immunoglobulin.

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Figure 1 Immunofluorescence pattern of patient septin-5-immunoglobulin G binding to mouse tissues Immunofluorescence pattern of patient septin-5-immunoglobulin G binding to mouse tissues (A–F) Patient serum produces synaptic staining patterns of cerebellar ML more than GL (A); Hi (B, C, and D); Th (C); Cx (D); enteric ganglia (arrow) and nerves (arrow heads) (E); and renal glomeruli (F). (G) Mouse cerebrum proteins, reduced, denatured, and separated electrophoretically, produced a ∼45-kDa band when probed with patients' IgGs (patients 1–6) but not healthy controls' IgGs. (H and I) Application of IgG eluted from a nitrocellulose strip containing the ∼45-KDa band to mouse tissue reproduced the patient's IgG staining pattern (E). Scale bar = 5 mm. Cx = cerebral cortex; GL = granular layer; Hi = hippocampus; ML = molecular layer; Th = thalamus. Josephe A. Honorat et al. Neurol Neuroimmunol Neuroinflamm 2018;5:e474 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.