Attenuation of Changes in Leukocyte Surface Markers and Complement Activation With Heparin-Coated Cardiopulmonary Bypass Oddvar Moen, MD, Kolbjørn Høgåsen,

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Attenuation of Changes in Leukocyte Surface Markers and Complement Activation With Heparin-Coated Cardiopulmonary Bypass Oddvar Moen, MD, Kolbjørn Høgåsen, MD, PhD, Erik Fosse, MD, PhD, Einar Dregelid, MD, Vibeke Brockmeier, MD, Per Venge, MD, PhD, Morten Harboe, MD, PhD, Tom Eirik Mollnes, MD, PhD The Annals of Thoracic Surgery Volume 63, Issue 1, Pages 105-111 (January 1997) DOI: 10.1016/S0003-4975(96)00743-6

Fig. 1 Concentrations of complement 3 activation products C3b, iC3b, and C3c (C3bc) and the terminal SC5b-9 complement complex (TCC) during cardiopulmonary bypass (CPB) in 12 patients having coronary artery bypass grafting with Duraflo II heparin-coated equipment and in 12 controls. Data are shown as the median value with interquartile range. (AU = arbitrary units; prota. = protamine sulfate; ∗ = p < 0.05 for median values between heparin-coated group versus control group by Wilcoxon test.) The Annals of Thoracic Surgery 1997 63, 105-111DOI: (10.1016/S0003-4975(96)00743-6)

Fig. 2 Total leukocyte count and monocyte, neutrophil, and platelet counts (n × 109/L) (median and interquartile range) in patient groups defined in Fig. 1 legend. See text for significant differences. (CPB = cardiopulmonary bypass; prota. = protamine sulfate.) The Annals of Thoracic Surgery 1997 63, 105-111DOI: (10.1016/S0003-4975(96)00743-6)

Fig. 3 Plasma concentrations of lactoferrin and myeloperoxidase (median and interquartile range) in patient groups defined in Fig. 1 legend. No significant differences were demonstrated between groups. (Abbreviations are the same as in Fig. 2.) The Annals of Thoracic Surgery 1997 63, 105-111DOI: (10.1016/S0003-4975(96)00743-6)

Fig. 4 Relative fluorescence intensity (median and interquartile range) on monocytes and neutrophils (quantified in flow cytometry), indicating expression of complement receptor (CR) 1 (CD35), CR3 (CD11b/CD18), CR4 (CD11c/CD18), and L-selectin in patient groups defined in Fig. 1 legend. (Abbreviations are the same as in Fig. 2.) The Annals of Thoracic Surgery 1997 63, 105-111DOI: (10.1016/S0003-4975(96)00743-6)

Fig. 5 Relative fluorescence intensity (median and interquartile range) on platelets (quantified in flow cytometry), indicating expression of P-selectin (CD62) and CD41 (GPIIb/IIIa) in patient groups defined in Fig. 1 legend. No significant differences were demonstrated between groups. (Abbreviations are the same as in Fig. 2.) The Annals of Thoracic Surgery 1997 63, 105-111DOI: (10.1016/S0003-4975(96)00743-6)