Seizure - European Journal of Epilepsy The anti-depression effect of Xylaria nigripes in patients with epilepsy: A multicenter randomized double-blind study  Wei-Feng Peng, Xin Wang, Zhen Hong, Guo-Xing Zhu, Bing-Mei Li, Ze Li, Mei-Ping Ding, Zhi Geng, Zheng Jin, Ling Miao, Li-Wen Wu, Shao-Kang Zhan  Seizure - European Journal of Epilepsy  Volume 29, Pages 26-33 (July 2015) DOI: 10.1016/j.seizure.2015.03.014 Copyright © 2015 British Epilepsy Association Terms and Conditions

Fig. 1 Flow chart of enrollment and follow-up of patients. Seizure - European Journal of Epilepsy 2015 29, 26-33DOI: (10.1016/j.seizure.2015.03.014) Copyright © 2015 British Epilepsy Association Terms and Conditions

Fig. 2 (a) The total effective rate for depression in week 12 was significantly greater in the Wu Ling group than in the Placebo group, which had no difference between the two groups in weeks 2, 4 and 8, *P=0.002. (b, c) HAMD total score was significantly less while DHST was significantly greater in the Wu Ling group than in the Placebo group in week 12, #P=0.0367, *P=0.001. HAMD, Hamilton Depression Rating Scale. DHST, the difference in HAMD score before and after treatment. Seizure - European Journal of Epilepsy 2015 29, 26-33DOI: (10.1016/j.seizure.2015.03.014) Copyright © 2015 British Epilepsy Association Terms and Conditions

Fig. 3 The differences in total QOLIE-31 score, overall quality of life score and seizure worry score before and after 12 weeks of treatment were significantly greater in the Wu Ling group than in the Placebo group, #P<0.05, *P<0.01. QOLIE-31, the Quality of Life in Epilepsy Inventory-31. Seizure - European Journal of Epilepsy 2015 29, 26-33DOI: (10.1016/j.seizure.2015.03.014) Copyright © 2015 British Epilepsy Association Terms and Conditions