Prognostic significance of circulating tumor cells in bone marrow or peripheral blood as detected by qualitative and quantitative PCR in pediatric NPM-ALK–positive.

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Presentation transcript:

Prognostic significance of circulating tumor cells in bone marrow or peripheral blood as detected by qualitative and quantitative PCR in pediatric NPM-ALK–positive anaplastic large-cell lymphoma by Christine Damm-Welk, Kerstin Busch, Birgit Burkhardt, Jutta Schieferstein, Susanne Viehmann, Ilske Oschlies, Wolfram Klapper, Martin Zimmermann, Jochen Harbott, Alfred Reiter, and Willi Woessmann Blood Volume 110(2):670-677 July 15, 2007 ©2007 by American Society of Hematology

Sensitivity of the qualitative RT-PCR for NPM-ALK. Sensitivity of the qualitative RT-PCR for NPM-ALK. NPM-ALK–positive Karpas 299 cells were diluted in DG 75 Burkitt lymphoma cells. Christine Damm-Welk et al. Blood 2007;110:670-677 ©2007 by American Society of Hematology

Comparison of quantitative NPM-ALK PCR results between bone marrow and peripheral blood. Comparison of quantitative NPM-ALK PCR results between bone marrow and peripheral blood. Number of NPM-ALK copies/104 copies ABL in bone marrow and peripheral blood of 19 patients with a positive RT-PCR in bone marrow and blood. Christine Damm-Welk et al. Blood 2007;110:670-677 ©2007 by American Society of Hematology

Cumulative incidence of relapse of 80 analyzed ALCL patients according to qualitative PCR results for NPM-ALK in bone marrow. Cumulative incidence of relapse of 80 analyzed ALCL patients according to qualitative PCR results for NPM-ALK in bone marrow. Christine Damm-Welk et al. Blood 2007;110:670-677 ©2007 by American Society of Hematology

Quantitative NPM-ALK PCR results in bone marrow according to the outcome of the ALCL patients. Quantitative NPM-ALK PCR results in bone marrow according to the outcome of the ALCL patients. Normalized NPM-ALK copy numbers (copies NPM-ALK/104 copies ABL) in bone marrow of the 74 patients with either a negative qualitative BM PCR (= 0 copies NPM-ALK) or a positive qualitative BM PCR using quantitative PCR results. TRM indicates treatment related mortality; sec mal, second malignancy. Christine Damm-Welk et al. Blood 2007;110:670-677 ©2007 by American Society of Hematology

Outcome of ALCL patients according to quantitative PCR results for NPM-ALK in bone marrow. Outcome of ALCL patients according to quantitative PCR results for NPM-ALK in bone marrow. (A) Cumulative incidence of relapse and Kaplan-Meier estimates of (B) event-free survival and (C) overall survival of the 74 patients with either a negative qualitative BM PCR or a positive qualitative BM PCR using quantitative PCR results and a NPM-ALK cutoff copy number of 10/104 copies ABL (NCN). Christine Damm-Welk et al. Blood 2007;110:670-677 ©2007 by American Society of Hematology