Comparative study of endoscopic surveillance in hereditary diffuse gastric cancer according to CDH1 mutation status Emma Z. Mi, BA, Ella Z. Mi, BA, Massimiliano.

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Presentation transcript:

Comparative study of endoscopic surveillance in hereditary diffuse gastric cancer according to CDH1 mutation status Emma Z. Mi, BA, Ella Z. Mi, BA, Massimiliano di Pietro, MD, Maria O’Donovan, MD, FRCPath, Richard H. Hardwick, MD, FRCS, Susan Richardson, RGN, Hisham Ziauddeen, PhD, MRCPsych, Paul C. Fletcher, PhD, FRCPsych, Carlos Caldas, MD, FMedSci, Marc Tischkowitz, MD, PhD, Krish Ragunath, MD, FRCP, Rebecca C. Fitzgerald, MD, FMedSci Gastrointestinal Endoscopy Volume 87, Issue 2, Pages 408-418 (February 2018) DOI: 10.1016/j.gie.2017.06.028 Copyright © 2018 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 1 Detection of signet ring cell carcinoma (SRCC) on endoscopy. A, Examples of endoscopic lesions associated with foci of SRCC. From left to right: pale area, polyp, mucosal erosion. B, An additional case of a pale area positive for SRCC, with corresponding autofluorescence imaging and narrow-band imaging magnification image and histology showing a focus of SRCC. Narrow-band imaging magnification demonstrates loss of pit and irregular vessels. Gastrointestinal Endoscopy 2018 87, 408-418DOI: (10.1016/j.gie.2017.06.028) Copyright © 2018 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 2 Risk of signet ring cell carcinoma (SRCC) on endoscopy by CDH1 mutation status. A, Survival analysis of progression to SRCC on endoscopy by CDH1 mutation status. B, Cumulative hazard for SRCC by CDH1 mutation status. CDH1-NPVD, CDH1 no pathogenic variant detected. Gastrointestinal Endoscopy 2018 87, 408-418DOI: (10.1016/j.gie.2017.06.028) Copyright © 2018 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 3 Timing of findings of signet ring cell carcinoma on endoscopy in CDH1+ patients. Gastrointestinal Endoscopy 2018 87, 408-418DOI: (10.1016/j.gie.2017.06.028) Copyright © 2018 American Society for Gastrointestinal Endoscopy Terms and Conditions