From Hype to Hope: The Gut Microbiota in Enteric Infectious Disease

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From Hype to Hope: The Gut Microbiota in Enteric Infectious Disease Peter T. McKenney, Eric G. Pamer Cell Volume 163, Issue 6, Pages 1326-1332 (December 2015) DOI: 10.1016/j.cell.2015.11.032 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Colonization Resistance The gut microbiome contributes to colonization resistance through at least four inter-related functions. (1) Direct inhibition of neighboring bacteria via the production of toxic compounds. (2) Maintenance of the mucus barrier and underlying intestinal epithelium. (3) Regulation of the immune response. (4) Efficient utilization of host nutrients, such as mucus polysaccharides, by commensals may serve to limit the expansion of less well-adapted invading microbes. Cell 2015 163, 1326-1332DOI: (10.1016/j.cell.2015.11.032) Copyright © 2015 Elsevier Inc. Terms and Conditions