Anabolic steroid–induced hypogonadism: diagnosis and treatment

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Presentation transcript:

Anabolic steroid–induced hypogonadism: diagnosis and treatment Cyrus D. Rahnema, B.S., Larry I. Lipshultz, M.D., Lindsey E. Crosnoe, B.S., Jason R. Kovac, M.D., Ph.D., Edward D. Kim, M.D. Fertility and Sterility Volume 101, Issue 5, Pages 1271-1279 (May 2014) DOI: 10.1016/j.fertnstert.2014.02.002 Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Illustrates the pathophysiology of anabolic-androgenic steroid (AAS)–induced hypogonadism (ASIH) and the mechanism of action of selected treatment strategies. Recovery therapy focuses on estrogen blockade at the level of the hypothalamus to encourage GnRH pulsation and gonadotropin release to restart the hypothalamic-pituitary-gonadal axis and increase testosterone production. Fertility and Sterility 2014 101, 1271-1279DOI: (10.1016/j.fertnstert.2014.02.002) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Suggested treatment algorithm for symptomatic anabolic-androgenic steroid–induced hypogonadism (ASIH). SERM = selective estrogen receptor modulator; TRT = testosterone replacement therapy. Fertility and Sterility 2014 101, 1271-1279DOI: (10.1016/j.fertnstert.2014.02.002) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions