High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric.

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The incidence of HIV associated Castleman’s disease Professor Mark Bower Chelsea & Westminster Hospital London, UK.

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Date of download: 6/24/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Interleukin 6 and Interleukin 8 as Potential Biomarkers.

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High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric Castleman disease in HIV-infected patients by Eric Oksenhendler, Guislaine Carcelain, Yoshiyasu Aoki, Emmanuelle Boulanger, Anne Maillard, Jean-Pierre Clauvel, and Félix Agbalika Blood Volume 96(6):2069-2073 September 15, 2000 ©2000 by American Society of Hematology

Standard curve for quantitative PCR assays for HHV8 ORF26 gene Standard curve for quantitative PCR assays for HHV8 ORF26 gene.Shown are the Ct values from 4 assays at which a given input of HHV8 DNA-containing plasmid was detected by PCR. Plasmid concentrations tested ranged from 1 to 7.5 × 106 copies per reaction mixt... Standard curve for quantitative PCR assays for HHV8 ORF26 gene.Shown are the Ct values from 4 assays at which a given input of HHV8 DNA-containing plasmid was detected by PCR. Plasmid concentrations tested ranged from 1 to 7.5 × 106 copies per reaction mixture. A linear amplification was obtained for values between 30 and 7.5 × 106 copies. The Spearman rank coefficient of correlation (R) is given. Eric Oksenhendler et al. Blood 2000;96:2069-2073 ©2000 by American Society of Hematology

Comparisons between the 3 groups of patients Comparisons between the 3 groups of patients.Comparisons between control HHV8-seropositive HIV-infected patients (n = 12, 1 visit/patient) and the HIV-infected patients with MCD (n = 23) in asymptomatic remission of the disease (50 visits) and with active s... Comparisons between the 3 groups of patients.Comparisons between control HHV8-seropositive HIV-infected patients (n = 12, 1 visit/patient) and the HIV-infected patients with MCD (n = 23) in asymptomatic remission of the disease (50 visits) and with active symptomatic disease (45 visits) show a significant difference in the quantitative detection of HHV8 DNA copy numbers in PBMCs between the 3 groups (P < .0001) and a significant difference between the asymptomatic and the symptomatic groups in the level of plasma IL-6 (P = .0008) and IL-10 (P < .0001). Eric Oksenhendler et al. Blood 2000;96:2069-2073 ©2000 by American Society of Hematology

Correlations between the quantitative detection of HHV8 DNA copy numbers in PBMCs with the level of serum CRP (P < .0001), plasma IL-6 (P < .0001), and plasma IL-10 (P < .0001) in 23 HIV-infected patients (95 visits) with MCD.A possible correlation between ... Correlations between the quantitative detection of HHV8 DNA copy numbers in PBMCs with the level of serum CRP (P < .0001), plasma IL-6 (P < .0001), and plasma IL-10 (P < .0001) in 23 HIV-infected patients (95 visits) with MCD.A possible correlation between HHV8 copy numbers and plasma HIV-RNA was also noted (P = .08). Eric Oksenhendler et al. Blood 2000;96:2069-2073 ©2000 by American Society of Hematology

Longitudinal evaluation of HHV8 DNA copy numbers in PBMCs, serum CRP, plasma IL-6, and plasma IL-10.Longitudinal evaluation of HHV8 DNA copy numbers in PBMCs, serum CRP, plasma IL-6, and plasma IL-10 in 3 patients shows a strong correlation between these 4 ... Longitudinal evaluation of HHV8 DNA copy numbers in PBMCs, serum CRP, plasma IL-6, and plasma IL-10.Longitudinal evaluation of HHV8 DNA copy numbers in PBMCs, serum CRP, plasma IL-6, and plasma IL-10 in 3 patients shows a strong correlation between these 4 covariates in patient 2 (A) within 15 visits over a 25-month period and in patient 13 (B) within 10 visits over a 24-month period. Panel (C) shows a dramatic decrease in all biological markers during the first 4 weeks following the initiation of chemotherapy in patient 3. Eric Oksenhendler et al. Blood 2000;96:2069-2073 ©2000 by American Society of Hematology