A Jagged Road to Lymphoma Aggressiveness

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Presentation transcript:

A Jagged Road to Lymphoma Aggressiveness Vedran Radojcic, Ivan Maillard Cancer Cell Volume 25, Issue 3, Pages 261-263 (March 2014) DOI: 10.1016/j.ccr.2014.03.001 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Emerging Roles of Notch in Lymphoma Pathogenesis (A) Structure of Notch1 and Notch2 receptors with sites of activating mutations previously reported in lymphoid malignancies. T-ALL, T cell acute lymphoblastic leukemia/lymphoma; CLL, chronic lymphocytic leukemia; MCL, mantle cell lymphoma; SMZL, splenic marginal zone lymphoma; ICN, intracellular Notch; HD, heterodimerization domain; TMD, transmembrane domain. (B) Proposed model for crosstalk between lymphoma cells (LC) and endothelial cells (EC), with Jagged1/Notch2-driven effects on lymphoma aggressiveness (Cao et al., 2014). FGFR1, fibroblast growth factor receptor 1; FGF4, fibroblast growth factor 4; ICN, intracellular Notch. Cancer Cell 2014 25, 261-263DOI: (10.1016/j.ccr.2014.03.001) Copyright © 2014 Elsevier Inc. Terms and Conditions