Is infection with hypermutable Pseudomonas aeruginosa clinically significant?  Adi Auerbach, Eitan Kerem, Marc Victor Assous, Elie Picard, Maskit Bar-Meir 

Slides:



Advertisements
Similar presentations
Cheryl Cameron, Mark W. Lodes, William M. Gershan 
Advertisements

Christopher C. Miller, Christopher A
P. Whitaker, N. Shaw, J. Gooi, C. Etherington, S. Conway, D. Peckham 
Spread of colistin resistant non-mucoid Pseudomonas aeruginosa among chronically infected Danish cystic fibrosis patients  Helle Krogh Johansen, Samuel.
William G. Flight, Jonathan Shaw, Susan Johnson, A
Risk factors for age at initial Pseudomonas acquisition in the cystic fibrosis epic observational cohort  Margaret Rosenfeld, Julia Emerson, Sharon McNamara,
Early rise of anti-Pseudomonas antibodies and a mucoid phenotype of Pseudomonas aeruginosa are risk factors for development of chronic lung infection—A.
Epidemic Pseudomonas aeruginosa infection in patients with cystic fibrosis is not a risk factor for poor clinical Outcomes following lung transplantation 
Megan R. Nelson, Craig R. Adamski, Audrey Tluczek 
Urinary incontinence in 9���16��year olds with cystic fibrosis compared to other respiratory conditions and a normal group  W.J. Browne, C.J. Wood, M.
Measures of body habitus are associated with lung function in adults with cystic fibrosis: A population-based study  Doug L. Forrester, Alan J. Knox,
Laura Viviani, Baroukh M. Assael, Eitan Kerem 
Eitan Kerem, Michael Wilschanski, Nilsen L
A longitudinal analysis of chronic MRSA and Pseudomonas aeruginosa co-infection in cystic fibrosis: A single-center study  Maret L. Maliniak, Arlene A.
Cirrhosis and other liver disease in cystic fibrosis
The ease of breathing test tracks clinical changes in cystic fibrosis
Delayed publication of clinical trials in cystic fibrosis
Increased serum concentration of G-CSF in cystic fibrosis patients with chronic Pseudomonas aeruginosa pneumonia  P.Ø. Jensen, C. Moser, A. Kharazmi,
A. Oliver, A. Mena  Clinical Microbiology and Infection 
Controlled clinical trials in cystic fibrosis — are we doing better?
Long-term azitromycin treatment of cystic fibrosis patients with chronic Pseudomonas aeruginosa infection; an observational cohort study  Christine Rønne.
Anju Anand, Elizabeth Tullis, Anne Stephenson, Preyanka Abhyankar 
D. Stevens, P.J. Oades, N. Armstrong, C.A. Williams 
Claire J. Tipping, Rebecca L. Scholes, Narelle S. Cox 
Cystic fibrosis mortality trend in Italy from 1970 to 2011
Molecular detection of an atypical, highly resistant, clonal Pseudomonas aeruginosa isolate in cystic fibrosis patients  Deirdre Keating, Mary J. Crowe,
Gerd Döring, Patrick Flume, Harry Heijerman, J. Stuart Elborn 
Implementation of European standards of care for cystic fibrosis ��� Control and treatment of infection  J.S. Elborn, M. Hodson, C. Bertram  Journal of.
The Journal of Cystic Fibrosis: Sunny perspectives
A.H. Gifford  Journal of Cystic Fibrosis 
Differences in prevalence and treatment of Pseudomonas aeruginosa in cystic fibrosis centres in Denmark, Norway and Sweden  Per Kristian Knudsen, Hanne.
Economic effects of an eradication protocol for first appearance of Pseudomonas aeruginosa in cystic fibrosis patients: 1995 vs. 2009  Yolanda P. Lillquist,
Effectiveness of inhaled tobramycin in eradicating Pseudomonas aeruginosa in children with cystic fibrosis  Sanja Stanojevic, Valerie Waters, Joseph L.
Inhalation solutions — Which ones may be mixed
Physiologic endpoints for clinical studies for cystic fibrosis
Characterisation of mutations and genotype–phenotype correlation in cystic fibrosis: Experience from India  Shivaram S. Shastri, Madhulika Kabra, Sushil.
Sophia L. Markantonis, Anna Katelari, Eleni Pappa, Stavros Doudounakis 
E. Tschiedel, H. Grasemann, F. Ratjen  Journal of Cystic Fibrosis 
Colon Cancer in Cystic Fibrosis patients: Is this a growing problem?
Sally H. Pattison, Geraint B. Rogers, Martin Crockard, J
Anastasios Lekkas, Khin M. Gyi, Margaret E. Hodson 
Stenotrophomonas maltophilia in cystic fibrosis: Improved detection by the use of selective agar and evaluation of antimicrobial resistance  P. Goncalves-Vidigal,
Nasal polyposis in lung transplant recipients with cystic fibrosis
Eradication failure of newly acquired Pseudomonas aeruginosa isolates in cystic fibrosis  Malena Cohen-Cymberknoh, Noa Gilead, Silvia Gartner, Sandra.
Novel concepts in evaluating antimicrobial therapy for bacterial lung infections in patients with cystic fibrosis  Geraint B. Rogers, Lucas R. Hoffman,
Paternity in men with cystic fibrosis: a retrospective survey in France  Ingrid Duguépéroux, Dominique Hubert, Stéphane Dominique, Gil Bellis, Marc De.
Antimicrobial activity of fosfomycin and tobramycin in combination against cystic fibrosis pathogens under aerobic and anaerobic conditions  Gerard McCaughey,
Australian epidemic strain pseudomonas (AES-1) declines further in a cohort segregated cystic fibrosis clinic  Amanda L. Griffiths, Danielle F. Wurzel,
Segregation of children with CF diagnosed via newborn screening and acquisition of Pseudomonas aeruginosa  Karen O. McKay, Peter J. Cooper, Peter P. van.
Trends in pathogens colonising the respiratory tract of adult patients with cystic fibrosis, 1985–2005  F.A. Millar, N.J. Simmonds, M.E. Hodson  Journal.
Stationary biofilm growth normalizes mutation frequencies and mutant prevention concentrations in Pseudomonas aeruginosa from cystic fibrosis patients 
V. Thompson, N. Mayer-Hamblett, M. Kloster, D. Bilton, P.A. Flume 
J.E. Spahr, R.B. Love, M. Francois, K. Radford, K.C. Meyer 
L. Uppaluri, S.J. England, T.F. Scanlin  Journal of Cystic Fibrosis 
Susceptibility of multi-drug-resistant Pseudomonas aeruginosa in intensive care units: results from the European MYSTIC study group†   H. Goossens  Clinical.
D.F. Waterhouse, A.M. McLaughlin, C.G. Gallagher 
Intravenous monthly pulse methylprednisolone treatment for ABPA in patients with cystic fibrosis  Malena Cohen-Cymberknoh, Hannah Blau, David Shoseyov,
‘Peeling paint’ dermatitis as a presenting sign of cystic fibrosis
L. Nshimyumukiza, A. Bois, P. Daigneault, L. Lands, A. -M. Laberge, D
Beta-lactam allergy in adults with cystic fibrosis
Cheryl Cameron, Mark W. Lodes, William M. Gershan 
Patients with cystic fibrosis and normoglycemia exhibit diabetic glucose tolerance during pulmonary exacerbation  Noa Nezer M. Sc, David Shoseyov, Eitan.
Lutz Goldbeck, Sven Zerrer, Tim G. Schmitz  Journal of Cystic Fibrosis 
Khin M. Gyi, Margaret E. Hodson, Magdi Y. Yacoub 
David Adeboyeku, Sandra Scott, Margaret E. Hodson 
Increasing resistance of the Liverpool Epidemic Strain (LES) of Pseudomonas aeruginosa (Psa) to antibiotics in cystic fibrosis (CF)—A cause for concern? 
Elisabeth P. Dellon, Margaret W. Leigh, James R. Yankaskas, Terry L
B. Martha, D. Croisier, A. Fanton, K. Astruc, L. Piroth, F. Huet, P
Improved early diagnosis of Pseudomonas aeruginosa by real-time PCR to prevent chronic colonisation in a paediatric cystic fibrosis population  Elaine.
Early aggressive eradication therapy for intermittent Pseudomonas aeruginosa airway colonization in cystic fibrosis patients: 15 years experience  C.R.
Presentation transcript:

Is infection with hypermutable Pseudomonas aeruginosa clinically significant?  Adi Auerbach, Eitan Kerem, Marc Victor Assous, Elie Picard, Maskit Bar-Meir  Journal of Cystic Fibrosis  Volume 14, Issue 3, Pages 347-352 (May 2015) DOI: 10.1016/j.jcf.2014.09.011 Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Distribution of the logarithmic transformation of mutation frequency in hypermutable and non-hypermutable isolates (N=96). Median value is presented for both groups. Journal of Cystic Fibrosis 2015 14, 347-352DOI: (10.1016/j.jcf.2014.09.011) Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions