The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee.

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Presentation transcript:

The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial L. Gallelli, O. Galasso, D. Falcone, S. Southworth, M. Greco, V. Ventura, P. Romualdi, A. Corigliano, R. Terracciano, R. Savino, E. Gulletta, G. Gasparini, G. De Sarro Osteoarthritis and Cartilage Volume 21, Issue 9, Pages 1400-1408 (September 2013) DOI: 10.1016/j.joca.2013.06.026 Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Schematic representation of treatment groups. Osteoarthritis and Cartilage 2013 21, 1400-1408DOI: (10.1016/j.joca.2013.06.026) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Effects of NSAIDs on WOMAC score. All values are expressed means ± standard deviation for each treatment group (n = 15) and were evaluated as difference between the values at T1 and T0. Osteoarthritis and Cartilage 2013 21, 1400-1408DOI: (10.1016/j.joca.2013.06.026) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 IL-6 concentrations in synovial fluid before (T0) and after NSAID treatment for 14 days (T1) (n = 15) for each group. Osteoarthritis and Cartilage 2013 21, 1400-1408DOI: (10.1016/j.joca.2013.06.026) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 VEGF concentrations in synovial fluid before (T0) and after NSAID treatment for 14 days (T1) (n = 15) for each group. Osteoarthritis and Cartilage 2013 21, 1400-1408DOI: (10.1016/j.joca.2013.06.026) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 TNF-alpha concentrations in synovial fluid before (T0) and after NSAID treatment for 14 days (T1) (n = 15) for each group. Osteoarthritis and Cartilage 2013 21, 1400-1408DOI: (10.1016/j.joca.2013.06.026) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 Effects of celecoxib (400 mg/day), diclofenac (150 mg/day) and ibuprofen (1800 mg/day) for 14 days on JNK (panel A), p38 (panel B), ERK (panel C), and RAS (panel D) phosphorylation in enrolled patients compared to control patients. Densitometric evaluation of western blots is expressed as arbitrary units. Values are means ± standard deviation, n = 15 in each NSAID group; n = 10 in control group. Osteoarthritis and Cartilage 2013 21, 1400-1408DOI: (10.1016/j.joca.2013.06.026) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 7 Effects of celecoxib (400 mg/day), diclofenac (150 mg/day) and ibuprofen (1800 mg/day) for 14 days on caspase-3 activation in enrolled patients compared to control patients. The part of the blot in the MW range between 14 and 20 kDa is shown in order to visualize the active, cleaved form of caspase-3. Densitometric evaluation of western blots is expressed in arbitrary units. Values are means ± standard deviation, n = 15. Osteoarthritis and Cartilage 2013 21, 1400-1408DOI: (10.1016/j.joca.2013.06.026) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions