Mechanisms of action of interferon and nucleoside analogues

Slides:

Advertisements

Similar presentations

Interferons Cytokine family important for innate immunity against viruses Three classes of IFNs according to the receptor used Type I IFNs essential for.

Advertisements

CYTOKINES AND RECEPTORS DR SANJITA DAS. What Is A Cytokine? Low molecular weight proteins (30 KDa) Bind receptors, alter gene expression Can bind the.

Interferons Induction of synthesis Induction of antiviral activity Antiviral activities induced by interferons  and  Antiviral activities induced by.

EASL Clinical Practice Guidelines: Vascular diseases of the liver Journal of Hepatology Volume 64, Issue 1, Pages (January 2016) DOI: /j.jhep

Laurent Mailly, Mirjam B. Zeisel, Thomas F. Baumert

Host – hepatitis C viral interactions: The role of genetics

By uzair hashmi Interferon.

Therapeutic vaccines and immune-based therapies for the treatment of chronic hepatitis B: Perspectives and challenges Marie-Louise Michel, Qiang Deng,

Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: A systematic review Christian Thoma, Christopher P. Day, Michael.

An integration of deep viral suppression with sequential immune modulation (cocktail therapy) to restore antiviral capacity: The future of chronic hepatitis.

Tissue response compared to receptor occupation

Type I Interferon Signal Pathway. InterferonInterferon (IFNs) is a group of signaling proteins made and released by host cells in response to the presence.

Hepatic CD141+IFNλ+ DC subset: One against all?

Natalija Novak, MD Journal of Allergy and Clinical Immunology

Laurent L'homme, PhD, David Dombrowicz, PhD

Volume 52, Issue 3, Pages (March 2010)

Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

Volume 98, Issue 4, Pages (February 2010)

A Way to DAI Cell Host & Microbe

Figure 1 Regulation of key antiviral responses in pancreatic β cells

Signaling molecules as therapeutic targets in allergic diseases

Notch: Filling a Hole in T Helper 2 Cell Differentiation

Pathogenesis of primary biliary cirrhosis

Regulatory T-cell directed therapies in liver diseases

Sterol-izing Innate Immunity

Volume 44, Issue 2, Pages (February 2006)

JAK inhibitors in dermatology: The promise of a new drug class

Regulatory T-cell directed therapies in liver diseases

Hepatitis C core protein – The “core” of immune deception?

Signalling pathways in alcohol-induced liver inflammation

Therapeutic vaccines and immune-based therapies for the treatment of chronic hepatitis B: Perspectives and challenges Marie-Louise Michel, Qiang Deng,

Simon Haas, Andreas Trumpp Developmental Cell

Hepatocyte-like cells differentiated from human induced pluripotent stem cells (iHLCs) are permissive to hepatitis C virus (HCV) infection: HCV study.

Marc van der Valk, Hans L. Zaaijer, Arnon P. Kater, Janke Schinkel

Volume 53, Issue 4, Pages (October 2010)

A dive into the complexity of type I interferon antiviral functions

Maintaining Poise: Commensal Microbiota Calibrate Interferon Responses

Volume 45, Issue 4, Pages (October 2006)

Staying Alive: Cell Death in Antiviral Immunity

Timothy M. Block, Ju-Tao Guo Gastroenterology

Pattern Recognition Receptors

Lamins and Disease Cell

Volume 36, Issue 4, Pages (April 2012)

Mona Malz, Federico Pinna, Peter Schirmacher, Kai Breuhahn

Bin Gao, Hua Wang, Fouad Lafdil, Dechun Feng Journal of Hepatology

Emerging Role of ISG15 in Antiviral Immunity

Biologics and biomarkers for asthma, urticaria, and nasal polyposis

The Neurobiology of Zika Virus

Zika Virus Infection RIG-ged by Keratinocytes and Fibroblasts

Constitutive Antiviral Immunity at the Expense of Autoimmunity

Immunopathogenesis of hepatitis C virus infection

Negative Feedback Mechanisms and Their Roles during Pattern Formation

Matthew D. Daugherty, Harmit S. Malik Cell Host & Microbe

Mosquito Defense Strategies against Viral Infection

Signalling links in the liver: Knitting SOCS with fat and inflammation

Immunological techniques in viral hepatitis

Schematic summary of the mechanisms by which tick-borne Phlebovirus NSs proteins inhibit the canonical IFN induction and signaling pathways. Schematic.

Pathogenesis of primary biliary cirrhosis

Innate immunity and HCV

HIV and HLA Class I: An Evolving Relationship

Role of desmoplasia in cholangiocarcinoma and hepatocellular carcinoma

Antiviral Immunity and Circular RNA: No End in Sight

Are calcineurin inhibitors-free regimens ready for prime time?

Volume 40, Issue 1, Pages (January 2004)

T-bet Runs INTERFERence

Neurotrophins and Their Role in Pathogenesis of Alopecia Areata

Primary immunodeficiencies may reveal potential infectious diseases associated with immune-targeting mAb treatments László Maródi, MD, PhD, Jean-Laurent.

Philippe Metz, Antje Reuter, Silke Bender, Ralf Bartenschlager

Host – hepatitis C viral interactions: The role of genetics

Imposing specificity by localization: mechanism and evolvability

Presentation transcript:

Mechanisms of action of interferon and nucleoside analogues Howard Thomas, Graham Foster, Dimitris Platis Journal of Hepatology Volume 39, Pages 93-98 (January 2003) DOI: 10.1016/S0168-8278(03)00207-1

Fig. 1 Initial binding steps of interferon α/β to the receptor. The interferon ligand is presumed to bind to IFNAR2 first and then to IFNAR1, which stabilises the complex. There is no direct evidence for this model, however, it is a logical hypothesis based on the calculated binding constants for each receptor component. While IFNAR2 binds interferon with moderate affinity (KD⊇2–10 nM for interferon alpha-2), the intrinsic affinity of IFNAR1 is low (KD>100 nM), stabilizing the complex by approximately 10–20-fold. Taken from http://bioinfo.weizmann.ac.il/. Journal of Hepatology 2003 39, 93-98DOI: (10.1016/S0168-8278(03)00207-1)

Fig. 2 Interferon α/β JAK-STAT signalling pathway. Multiple interactions among the JAKs and STATs are responsible for a variety of signalling responses, with possible positive or negative regulatory roles on the transcriptional activation of ISGs. Taken from http://www.biology.ucsd.edu. Journal of Hepatology 2003 39, 93-98DOI: (10.1016/S0168-8278(03)00207-1)

Fig. 3 Time course of immune response. Interferons are the first line of defence against viral infections. They act very rapidly within hours or a few days after infection against a variety of viruses. Journal of Hepatology 2003 39, 93-98DOI: (10.1016/S0168-8278(03)00207-1)

Fig. 4 Interferon ‘priming’. Interferons are produced in response to a viral infection and spread to the nearby cells where they activate ISGs, which are responsible for the establishment of an ‘antiviral state’ by preventing viral replication and also alert the immune system. Journal of Hepatology 2003 39, 93-98DOI: (10.1016/S0168-8278(03)00207-1)

Journal of Hepatology 2003 39, 93-98DOI: (10 Journal of Hepatology 2003 39, 93-98DOI: (10.1016/S0168-8278(03)00207-1)

Journal of Hepatology 2003 39, 93-98DOI: (10 Journal of Hepatology 2003 39, 93-98DOI: (10.1016/S0168-8278(03)00207-1)