LRP1-deleted mice have a stunted phenotype and recapitulate pathophysiological aspects of stunting in humans. LRP1-deleted mice have a stunted phenotype.

Slides:

Advertisements

Similar presentations

Figure 1. The body weight changes over 8-weeks

Advertisements

Valsartan Protects Pancreatic Islets and Adipose Tissue From the Inflammatory and Metabolic Consequences of a High-Fat Diet in Mice by Banumathi K. Cole,

The biodistribution and pharmacokinetics of [68Ga]Ga-1 in the orthotopic xenograft mice using µPET dynamic acquisitions. The biodistribution and pharmacokinetics.

The mechanisms that regulate systemic resilience in humans and animals

Schematic representation of possible effects of different factors on systemic resilience. Schematic representation of possible effects of different factors.

Variance priming for spatially nonoverlapping prime–target pairs.

GPR124 expression in endothelial cells is responsible for the phenotypes observed in Gpr124−/− mice. GPR124 expression in endothelial cells is responsible.

Histological features of murine DSS-induced colitis.

Gene-expression changes associated with stunting.

Klotho reduction increases the expression of cytokine response factors in the CP. (A–C) ICAM1 (A and B) and IRF7 (C) immunoreactivity in the CP of 19-

H3K4me3 pattern association with functionally relevant genes and changes over time. H3K4me3 pattern association with functionally relevant genes and changes.

Object exploration times before (Pre) and after (Post) the 4-wk protocol. Object exploration times before (Pre) and after (Post) the 4-wk protocol. During.

Klotho reduction in CP primes hippocampal microglia for activation.

Volume 21, Issue 5, Pages (May 2015)

Outline of the problem and experimental approach.

Klotho depletion increases MHC class II expression in the CP

Metabolic effects of K107R and rosiglitazone treatment.

Klotho reduction causes macrophage invasion into the CP

Postnatal lethality, pleural effusion in endothelial-specific Piezo1 cKO mice. Postnatal lethality, pleural effusion in endothelial-specific Piezo1 cKO.

Extracellular GABA level is decreased by genetic deletion of Best1 or MAOB but increased by overexpression of MAOB. (A) Schematic illustration for microdialysis.

Figure 5 The role of Ly6Chi and Ly6Clo monocytes

C1ORF106 contributes to intestinal epithelial barrier function.

Volume 1, Issue 3, Pages (March 2005)

Distinct TF motifs are associated with decreased or increased H3K27 acetylation peaks in hypothyroidism. Distinct TF motifs are associated with decreased.

Expression of NCoR1∆ID in PAX8−/− mice does not reverse repression of T3-positive target genes. qPCR on the indicated pituitary (A) and neuronal (B) genes.

Sleep/wake phenotype of S551D mutant mice.

Volume 146, Issue 7, Pages e4 (June 2014)

Ifnlr1 is expressed in the epithelial fraction along the length of the intestine. Ifnlr1 is expressed in the epithelial fraction along the length of the.

Kinetics of CXC chemokine appearance after endotoxin injection.

IBD development correlates with peripheral T cell activation in DNR mice. IBD development correlates with peripheral T cell activation in DNR mice. (A)

Increased resistance of GPR55-deficient mice to indomethacin-induced intestinal permeability. Increased resistance of GPR55-deficient mice to indomethacin-induced.

Effect of PV1(RIPO) on s.c.

Rescue of the sel-12 Egl phenotype by PS1 and PS1ΔE9 expressed from arrays formed at a concentration of 2 μg/ml. Rescue of the sel-12 Egl phenotype by.

Coregulation of VGAT and cGMP levels by dopamine.

Transfer of NRP1-expressing bone marrow improves the metabolic phenotype of LysM-Cre-Nrp1fl/fl mice. Transfer of NRP1-expressing bone marrow improves the.

Responses to high Pi diet in Fgfr1-cKO mice.

Fig. 6 Transmissibility of adiposity from humanized mice to germ-free recipients. Transmissibility of adiposity from humanized mice to germ-free recipients.

Exosomes transfected with obesity-associated miRNAs induce glucose intolerance dissociated from obesity. Exosomes transfected with obesity-associated miRNAs.

IL-10R-deficient macrophages secrete IL-23, inducing IL-22 secretion by ILC3 and TH17 cells. IL-10R-deficient macrophages secrete IL-23, inducing IL-22.

Differential Cre-ERT activity and PTEN deletion in endometrial epithelial and stromal compartments. Differential Cre-ERT activity and PTEN deletion in.

TNAP and IAP t1/2s and N-glycan remodeling following zanamivir treatment. TNAP and IAP t1/2s and N-glycan remodeling following zanamivir treatment. (A.

Median percentage weight change (left panels) and median weight (right panels) by birth weight groups as a function of time after (A) vaginal delivery.

Unchanged worm burden and microfilaremia in basophil-deficient mice compared with their basophil-competent littermates. Unchanged worm burden and microfilaremia.

Tamoxifen injections induce DNA damage response signaling in αMHC-MerCreMer mice.αMHC-MerCreMer+/+ mice received an injection of 60 μg/g body weight of.

Deletion of neuronal insulin receptor signaling reduces TG secretion, while the targeted knockout of insulin receptors restricted to the periphery increases.

Correlation between Ti→jS(r) and Ti→jM(r) for pair of locations (gray dots) separated by a distance of (A) r=1 km, (B) r=5 km, (C) r=20 km, (D) r=50 km,

1018-NT-β-cell clusters protect mice from STZ-induced diabetes.

Transplantation of the ω3-modified microbiome as a relevant way to preserve a lean phenotype in mice fed the HFHS diet. Transplantation of the ω3-modified.

Tamoxifen injections cause dose-dependent lethal heart failure in αMHC-MerCreMer mice. Tamoxifen injections cause dose-dependent lethal heart failure in.

Appearance of insulin in plasma and CSF at different times after the administration of subcutaneous DET and GLAR in mice and the effect of chronic DET.

ΑGLP-1R−/− mice show glucose intolerance and disturbed glucagon secretion in response to i.p. glucose administration. αGLP-1R−/− mice show glucose intolerance.

Treatment of ob/ob mice with TTR-ASOs reduces adipose tissue inflammation. Treatment of ob/ob mice with TTR-ASOs reduces adipose tissue inflammation. A:

Chop deletion preserves β-cell function in P58IPK−/− mice.

COX-2 deletion in macrophages led to increased renal macrophage infiltration in diabetic mice. COX-2 deletion in macrophages led to increased renal macrophage.

Alterations in epithelial permeability of the intestines of mice lacking afadin, nectin-2 and nectin-3. Alterations in epithelial permeability of the intestines.

AP2-Cre–mediated IKKβ deletion results in similar defects in adipose remodeling and accentuated inflammatory responses after HF feeding. aP2-Cre–mediated.

Loss of Phb2 in β-cells induces development of diabetes over a 3-week period in β-Phb2−/− mice. Loss of Phb2 in β-cells induces development of diabetes.

Fig. 1 Lkb1 loss leads to a complex neural crest phenotype.

Stress-induced release of inflammatory monocytes from the bone marrow into circulation was attenuated by MTP. Male C57BL/6 mice were injected daily with.

Stress-induced release of inflammatory monocytes from the bone marrow into circulation was prevented by ADX. Male C57BL/6 mice were subjected to sham or.

Apoptotic cell index percentage (a and b) and mitotic cell index percentage (c and d) in small intestinal (a and c) and midcolonic (b and d) crypts of.

Whole-mount analysis of tumor induced lymphatic sprouting by confocal microscopy. Whole-mount analysis of tumor induced lymphatic sprouting by confocal.

Mean weight change from original weight of (a) BALB/c (b) DBA/2 mice after one (♦) or two (▴) injections of 10 mg/kg and one (▪) or two (×) injections.

Mice with a B cell–specific deletion of Ets1 have increased memory phenotype B cells but no increase in switching to IgG1. Mice with a B cell–specific.

Wild-type mice weight following 6-thio-dG and 6-thioguanine treatment.

Effect of MZ treatment on lung colony formation in an experimental metastasis. Effect of MZ treatment on lung colony formation in an experimental metastasis.

Bacterial antigen encounter occurs during a specific preweaning interval, is dependent on GCs, and correlates with the presence of colonic GAPs. Bacterial.

Mice with a B cell–specific deletion of Ets1 do not have increased CD4+ T cell activation. Mice with a B cell–specific deletion of Ets1 do not have increased.

Fig. 3 The human FABP7 point mutation phenotype is recapitulated in Fabp7 KO mice, which also showed sleep fragmentation. The human FABP7 point mutation.

Fig. 5 Effects of in vivo blockade of TLR9 on adipose tissue inflammation and insulin resistance in WT mice. Effects of in vivo blockade of TLR9 on adipose.

Presentation transcript:

LRP1-deleted mice have a stunted phenotype and recapitulate pathophysiological aspects of stunting in humans. LRP1-deleted mice have a stunted phenotype and recapitulate pathophysiological aspects of stunting in humans. (A) LRP1 RNA levels in whole blood from 1-y-old control (Con) or stunted (St) children. ENO3 was chosen as an unaffected control. (B) Percentage weight gain in LRP-1fl/flCre-ERt2+ (LRP1−) and LRP-1+/+Cre-ERt2+ (LRP1+) mice after injection of tamoxifen. ***P < 0.001. (C) Appearance of LRP1+ and LRP1− littermates 40 d postinjection of tamoxifen. (D) Inguinal fat pad weight in LRP+ and LRP− mice. Each dot represents one animal. (E) Levels of Ly6Chi inflammatory macrophages in intestinal lamina propria from LRP1+ and LRP1− mice. (F) Serum FITC dextran levels in LRP1+ and LRP1− mice at 0 and 28 d posttamoxifen treatment. Robin Uchiyama et al. PNAS 2018;115:48:E11264-E11273 ©2018 by National Academy of Sciences