Genomics of epidemic pathogens

Slides:

Advertisements

Similar presentations

Genomic analysis of three African strains of Bacillus anthracis demonstrates that they are part of the clonal expansion of an exclusively pathogenic bacterium.

Advertisements

Models for the organisation of hospital infection control and prevention programmes B. Gordts Clinical Microbiology and Infection Volume 11, Pages

L.H. Su, T.L. Wu, C.H. Chiu Clinical Microbiology and Infection

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

L. Boyanova Clinical Microbiology and Infection

Lipooligosaccharide locus class of Campylobacter jejuni: sialylation is not needed for invasive infection P. Ellström, B. Feodoroff, M.-L. Hänninen,

C.N. van Ettekoven, D. van de Beek, M.C. Brouwer

Gut bacterial microbiota and obesity

L.H. Su, T.L. Wu, C.H. Chiu Clinical Microbiology and Infection

Approach to diagnosis of infective endocarditis

Herpes zoster in non-hospitalized children

Migrant health—a cause for concern?

Clinical characteristics of Haemophilus influenzae meningitis in Denmark in the post- vaccination era T.I. Pedersen, M. Howitz, C. Østergaard Clinical.

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

A.K. Reddy, P. Garg, I. Kaur Clinical Microbiology and Infection

J.-P. Van geertruyden Clinical Microbiology and Infection

R. Cantón Clinical Microbiology and Infection

Genital Chlamydia trachomatis infections

E. Cambau, M. Drancourt Clinical Microbiology and Infection

Louis Pasteur, from crystals of life to vaccination

How to evaluate and predict the ecologic impact of antibiotics: the pharmaceutical industry view from research and development R. Bax Clinical Microbiology.

Chlamydia trachomatis infections in heterosexuals attending sexually transmitted disease clinics in Slovenia D. Kese, M. Maticic, M. Potocnik Clinical.

Non-antibiotic strategies for sepsis

The importance of enterovirus surveillance in a Post-polio world

Clinical Microbiology and Infection

Tracking changes in the vraSR and graSR two component regulatory systems during the development and loss of vancomycin non-susceptibility in a clinical.

Vector control: a cornerstone in the malaria elimination campaign

Training for the infectious diseases speciality in Norway

A. Fajardo, J.F. Linares, J.L. Martínez

B. Gordts Clinical Microbiology and Infection

CMI editorial report 2011 Clinical Microbiology and Infection

Clinical Microbiology and Infection

The clinical efficacy of triclosan/copolymer and other common therapeutic approaches to periodontal health R.M. Davies Clinical Microbiology and Infection

Comparative in vitro activity of ertapenem against bacterial pathogens isolated from patients with lower respiratory tract infections P.S. Hicks, B.

Effects of gentamicin monotherapy for the initial treatment of community-onset complicated non-obstructive acute pyelonephritis due to Enterobacteriaceae.

The occurrence of Legionella species other than Legionella pneumophila in clinical and environmental samples in Denmark identified by mip gene sequencing.

Elements of design: the knowledge on which we build

Levofloxacin in the treatment of ventilator-associated pneumonia

G. Pappas Clinical Microbiology and Infection

Metagenomics and probiotics

Previously unknown species of Aspergillus

Laboratory diagnosis of Clostridium difficile disease

The practice of travel medicine in Europe

T.M. File Clinical Microbiology and Infection

Update on antifungal resistance in Aspergillus and Candida

Community-acquired pneumonia: epidemiologic and clinical consideration

Abstracts cont. Clinical Microbiology and Infection

Pandemic lineages of extraintestinal pathogenic Escherichia coli

Accurate hepatitis C virus genotyping and selection of optimal therapy: lessons from a St Petersburg strain infection E. Knops, E. Heger Clinical Microbiology.

Twelve years of fluconazole in clinical practice: global trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida

Circulation of international clones of levofloxacin non-susceptible Streptococcus pneumoniae in Taiwan Y.-C. Hsieh, L.-Y. Chang, Y.-C. Huang, H.-C. Lin,

An after-hours clinical liaison blood culture service—is it worth it?

Statin use and clinical outcomes among pneumonia patients

Clinical Microbiology and Infection

I. Bitar, A. Piazza Clinical Microbiology and Infection

Overview of cefixime use in community-acquired infections

K. Kaier, N.T. Mutters, U. Frank Clinical Microbiology and Infection

The atypical pneumonias: clinical diagnosis and importance

Facilitating learning and change in physicians: Implications for a system of continuing medical education in Europe Robert D. Fox Clinical Microbiology.

Abstracts Clinical Microbiology and Infection

Plague in the genomic area

Modelling during an emergency: the 2009 H1N1 influenza pandemic

New oral cephalosporins in pediatric community-acquired infections

J.L. Balcázar Clinical Microbiology and Infection

G.C. Schito Clinical Microbiology and Infection

Community-acquired acute bacterial meningitis in the elderly in Turkey

Impact of antibiotic restrictions: the patient's perspective

Comparative study of pediculicidal effect of medical plants

CMI readers' survey Clinical Microbiology and Infection

The future of diagnostic bacteriology

Presentation transcript:

Genomics of epidemic pathogens K. Georgiades Clinical Microbiology and Infection Volume 18, Issue 3, Pages 213-217 (March 2012) DOI: 10.1111/j.1469-0691.2012.03781.x Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Creation of an epidemic pathogen. Non-specialized bacterial species constitute ‘pre-species’ that have a community lifestyle and are able to exchange genes. After specialization, the number of horizontal gene transfers (HGTs) is reduced, until total genetic isolation has been acheived. Only gene loss is then possible, the bacterium is deregulated, and virulence capacity is initiated. The arrows show HGT and gene loss. TA, toxin–antitoxin. Clinical Microbiology and Infection 2012 18, 213-217DOI: (10.1111/j.1469-0691.2012.03781.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions