Christopher Hine, James R. Mitchell  Cell Stem Cell 

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Saying No to Drugs: Fasting Protects Hematopoietic Stem Cells from Chemotherapy and Aging  Christopher Hine, James R. Mitchell  Cell Stem Cell  Volume 14, Issue 6, Pages 704-705 (June 2014) DOI: 10.1016/j.stem.2014.05.016 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Fasting Ameliorates Effects of Chemotherapy and Aging on Bone Marrow Prolonged fasting boosts bone marrow hematopoietic stem cell (HSC) self-renewal and increases resistance to chemotherapeutic toxicity and aging-related loss of homeostasis through decreased IGF-1/PKA signaling. This results in maintenance of lymphoid cell (LC) and myeloid cell (MC) numbers and ratios and improved immune function. Cell Stem Cell 2014 14, 704-705DOI: (10.1016/j.stem.2014.05.016) Copyright © 2014 Elsevier Inc. Terms and Conditions

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