Vincentius J. A. Verlinden, MSc, Jos N

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Presentation transcript:

Structural and Microstructural Brain Changes Predict Impairment in Daily Functioning Vincentius J.A. Verlinden, MSc, Jos N. van der Geest, PhD, Marius de Groot, MSc, Albert Hofman, MD, PhD, Wiro J. Niessen, PhD, Aad van der Lugt, MD, PhD, Meike W. Vernooij, MD, PhD, M. Arfan Ikram, MD, PhD The American Journal of Medicine Volume 127, Issue 11, Pages 1089-1096.e2 (November 2014) DOI: 10.1016/j.amjmed.2014.06.037 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure Structural and microstructural brain changes on magnetic resonance imaging. Left on the image corresponds to right in the brain. (A) Lacunar infarct (arrow) on T1-weighted image. (B) White matter lesions (arrow) on fluid attenuation inversion recovery (FLAIR) image. (C) Cerebral microbleed (arrow) on T2*-weighted image. (D) Tissue segmentation with each tissue type represented in a different gray value (darkest gray = cerebrospinal fluid, gray = gray matter, light gray = normal-appearing white matter, white = white matter lesion). (E) Diffusion tensor imaging (DTI) map of fractional anisotropy with larger values indicating larger anisotropy. (F) DTI map of mean diffusivity with larger values indicating larger diffusivity. The American Journal of Medicine 2014 127, 1089-1096.e2DOI: (10.1016/j.amjmed.2014.06.037) Copyright © 2014 Elsevier Inc. Terms and Conditions