The origins of age-related proinflammatory state

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The origins of age-related proinflammatory state by Luigi Ferrucci, Annamaria Corsi, Fulvio Lauretani, Stefania Bandinelli, Benedetta Bartali, Dennis D. Taub, Jack M. Guralnik, and Dan L. Longo Blood Volume 105(6):2294-2299 March 15, 2005 ©2005 by American Society of Hematology

Mean values of inflammatory markers according to sex and age group expressed as number of standard deviations from the population mean to make them independent of different units of measure. Mean values of inflammatory markers according to sex and age group expressed as number of standard deviations from the population mean to make them independent of different units of measure. (Top row) indicates IL-6; □, IL-6r; ▴, IL-1ra; and ○, IL-18. (Bottom row) indicates CRP; □, fibrinogen. Luigi Ferrucci et al. Blood 2005;105:2294-2299 ©2005 by American Society of Hematology

Age regression coefficients and their 95% CIs estimated from linear models predicting level of inflammatory markers. Age regression coefficients and their 95% CIs estimated from linear models predicting level of inflammatory markers. Model “a” estimates the crude affect of age; model “b” is adjusted for cardiovascular risk factors; model “c” is also adjusted for subclinical cardiovascular diseases; and model “d” is adjusted for CHD, CHF, stroke, PAD, COPD, diabetes, hypertension, osteoporosis, CFR, cancer, dementia, and depression. R2 values reported below the confidence interval are for the model used to estimate the age regression coefficients. Luigi Ferrucci et al. Blood 2005;105:2294-2299 ©2005 by American Society of Hematology

Mean values (dashed lines) and 95% CIs (gray shaded areas) of inflammatory markers estimated for men and women of different age groups, under the assumption of low risk profile and no major morbidity. Mean values (dashed lines) and 95% CIs (gray shaded areas) of inflammatory markers estimated for men and women of different age groups, under the assumption of low risk profile and no major morbidity. The continuous lines are crude mean values calculated in 51 healthy men and 45 healthy women with low risk profile and no morbidity. None of these healthy participants was older than 85 years. Luigi Ferrucci et al. Blood 2005;105:2294-2299 ©2005 by American Society of Hematology