Platelet proinflammatory activity in clinically stable patients with CF starts in early childhood Alexander Sturm, Helge Hebestreit, Corinne Koenig,

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Platelet proinflammatory activity in clinically stable patients with CF starts in early childhood Alexander Sturm, Helge Hebestreit, Corinne Koenig, Ulrich Walter, Ralf Grossmann Journal of Cystic Fibrosis Volume 9, Issue 3, Pages 179-186 (May 2010) DOI: 10.1016/j.jcf.2009.12.004 Copyright © 2010 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Soluble markers of platelet activation and platelet–leukocyte aggregates. Soluble P-selectin (sCD62P), soluble CD40 ligand (sCD40L), percentage of platelet–neutrophil and platelet–monocyte aggregates of patients (▲) and controls (○) are plotted over the age. $ Percent of platelet-positive neutrophils/monocytes are shown relatively to the number of totally counted neutrophils/monocytes. r- and p-values as determined by Spearman Rank correlation are indicated. In controls, there was a significant correlation of platelet–neutrophil and platelet–monocyte aggregate counts with the age. Journal of Cystic Fibrosis 2010 9, 179-186DOI: (10.1016/j.jcf.2009.12.004) Copyright © 2010 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 Platelet hemostatic function. Panel a shows baseline PAC-1-binding to unstimulated platelets in patients and controls subgroups. PAC-1-binding to TRAP-6 activated platelets is demonstrated in Panel b. Both PAC-1-binding to unstimulated and activated platelets were significantly decreased in older patients and patients with higher markers of chronic inflammation. p-values resulting from Kruskal–Wallis analysis are shown (p<0.05 was considered to indicate a significant difference). * indicates a significant difference between all patients and controls, ° indicates a significant difference between old patients and old controls (p<0.01 resulting from Bonferroni-corrected Mann–Whitney U-Test was considered to indicate a significant difference between subgroups). ‡Subgroups with high CRP and high IgG were not identical. Journal of Cystic Fibrosis 2010 9, 179-186DOI: (10.1016/j.jcf.2009.12.004) Copyright © 2010 European Cystic Fibrosis Society. Terms and Conditions