Nat. Rev. Neurol. doi: /nrneurol

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Nat. Rev. Neurol. doi:10.1038/nrneurol.2016.167 Figure 3 Raised cerebrospinal fluid pressure in a patient with HIV-associated cryptococcal meningitis Figure 3 | Raised cerebrospinal fluid pressure in a patient with HIV-associated cryptococcal meningitis. Depicted here is time course of changes in cerebrospinal fluid (CSF) pressure, visual acuity, and volume of CSF drained through a temporary lumbar drain in situ over 11 days. Arrows indicate times of lumbar puncture. During the third week of antifungal therapy, and despite the fact that CSF cultures had become negative, the patient developed severely raised CSF pressure that was unresponsive to repeated daily lumbar punctures, but did respond to CSF drainage via a temporary lumbar drain. Symptoms of high CSF pressure recurred when the drain was clamped after 6 days, but did not recur when it was clamped and then removed after 10 days. CF, counting fingers (indicating severely reduced visual acuity). Adapted with permission from Elsevier Ltd © Macsween, K. F. et al. J. Infect. 51, e221-e224 (2005). Adapted with permission from Elsevier Ltd © Macsween, K. F. et al. J. Infect. 51, e221‑e224 (2005). Williamson, P. R. et al. (2016) Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy Nat. Rev. Neurol. doi:10.1038/nrneurol.2016.167