Animating the model figure Janet H. Iwasa  Trends in Cell Biology  Volume 20, Issue 12, Pages 699-704 (December 2010) DOI: 10.1016/j.tcb.2010.08.005 Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 1 A dynamic model of clathrin-mediated endocytosis. A series of still frames from an animation depicting clathrin-mediated endocytosis, completed in collaboration with Tomas Kirchhausen (Harvard Medical School). The full animation can be viewed and downloaded from the following website: http://iwasa.hms.harvard.edu. (a) A single clathrin triskelion is bound to an adaptor protein on the cell membrane. (b) Additional triskelions and adaptor proteins are recruited, and the membrane begins to deform. Soon after assembly of the clathrin cage is complete (c), the clathrin disassembly factors HSC70 and auxilin are recruited to the newly formed vesicle (d), causing clathrin triskelions to untwist (e) and leave the vesicle (f). Trends in Cell Biology 2010 20, 699-704DOI: (10.1016/j.tcb.2010.08.005) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 2 The development of an articulated 3D model of dynein. Vector illustration (a) and physical model (b) of dynein (both images courtesy of Samara Reck-Peterson). (c) Screen capture image of a preliminary articulated model of dynein, created in collaboration with Samara Reck-Peterson and her group (Harvard Medical School). The AAA motor ring is shown green, the linker domain light blue, GST dimerization domains dark blue, coiled coil yellow and the microtubule-binding domain orange. Wireframe circles and text indicate the location of user-controllable manipulation pivots. (d) A rendered still image of an animation showing a modified, simpler version of the articulated model. Trends in Cell Biology 2010 20, 699-704DOI: (10.1016/j.tcb.2010.08.005) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 3 Visualizing models of the centriole central tubule using 3D PDFs. Screen capture images of models as viewed in Adobe Acrobat Reader are shown. The models were created in collaboration with Tomer Avidor-Reiss and Jay Gopalakrishnan (Harvard Medical School). (a) and (c) Views of the stacked ring model of the central tubule. (b) and (d) The helical model. (c) and (d) A thin slice of the centriole models can be viewed using the cross-section tool. Red lines indicate where an invisible cross-section plane (parallel with the y-axis) intersects the model. The central tubule is shown orange, spokes yellow and microtubules green. Trends in Cell Biology 2010 20, 699-704DOI: (10.1016/j.tcb.2010.08.005) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure I Illustrations of physical models that have played important roles in chemistry and biology. Trends in Cell Biology 2010 20, 699-704DOI: (10.1016/j.tcb.2010.08.005) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure I Still images from animations created using different styles of rendering. Trends in Cell Biology 2010 20, 699-704DOI: (10.1016/j.tcb.2010.08.005) Copyright © 2010 Elsevier Ltd Terms and Conditions