Linking Protein and RNA Function within the Same Gene

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Linking Protein and RNA Function within the Same Gene Anthony Szempruch, Mitchell Guttman Cell Volume 168, Issue 5, Pages 753-755 (February 2017) DOI: 10.1016/j.cell.2017.02.014 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 UV Damage Induces Alternative Last Exon Inclusion Resulting in a Functional lncRNA with Antagonistic Properties to the Protein Produced from the Same Gene The full length ASCC3 transcript functions to repress transcription after UV damage. However, UV treatment results in the upregulation of RNA transcripts containing alternative last exons. In the case of ASCC3, its short RNA isoform is retained within the nucleus, where it functions as a lncRNA to activate transcription allowing for transcriptional recovery after UV damage. Cell 2017 168, 753-755DOI: (10.1016/j.cell.2017.02.014) Copyright © 2017 Elsevier Inc. Terms and Conditions