Philip E. Cryer, MD The American Journal of Medicine

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Presentation transcript:

Death during Intensive Glycemic Therapy of Diabetes: Mechanisms and Implications Philip E. Cryer, MD The American Journal of Medicine Volume 124, Issue 11, Pages 993-996 (November 2011) DOI: 10.1016/j.amjmed.2011.08.008 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure Potential mechanism of iatrogenic hypoglycemia-induced hypoglycemia-associated autonomic failure (HAAF) mediated sudden death in diabetes: cardiovascular HAAF causing reduced baroreceptor sensitivity and metabolic HAAF, leading to an episode of hypoglycemia that increases sympathoadrenal system activity, which triggers a fatal ventricular arrhythmia in the setting of reduced baroreflex sensitivity. The American Journal of Medicine 2011 124, 993-996DOI: (10.1016/j.amjmed.2011.08.008) Copyright © 2011 Elsevier Inc. Terms and Conditions