Cardiac Clocks and Preclinical Translation

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Cardiac Clocks and Preclinical Translation Priya Mistry, BSc, Austin Duong, BSc, MBS, Lorrie Kirshenbaum, PhD, Tami A. Martino, PhD Heart Failure Clinics Volume 13, Issue 4, Pages 657-672 (October 2017) DOI: 10.1016/j.hfc.2017.05.002 Copyright © 2017 The Author(s) Terms and Conditions

Fig. 1 The molecular circadian clock mechanism cycles in virtually all cells, including cardiomyocytes, and plays a direct role in regulating the daily output of thousands of genes, proteins, and metabolites. These in turn play key roles in regulating the structure and function of the healthy heart and contribute to cardiac remodeling and the pathophysiology of heart disease. Heart Failure Clinics 2017 13, 657-672DOI: (10.1016/j.hfc.2017.05.002) Copyright © 2017 The Author(s) Terms and Conditions