Figure 2 Podocyte dysfunction is a common feature of renal injury

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Figure 2 Podocyte dysfunction is a common feature of renal injury Figure 2 | Podocyte dysfunction is a common feature of renal injury. The podocytes of a | control mice and c | healthy people display primary and secondary processes with tertiary foot processes that interdigitate regularly with neighbouring podocytes. b | After adriamycin treatment, mice develop chronic kidney disease with characteristic foot process effacement. d | A representative glomerulus from a patient who experienced podocytopathy after an iatrogenic toxic renal injury, showing diffuse loss of podocyte cytoarchitecture, extensive foot process effacement and endothelial injury of the glomerular capillaries. Images are scanning electron micrographs. Perico, L. et al. (2016) Podocyte–actin dynamics in health and disease Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.127