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Volume 25, Issue 2, Pages 83-88 (June 2018) Increased glomerular Bax/Bcl2 ratio is positively correlated with glomerular sclerosis in lupus nephritis Ghada Hosny, Wesam Ismail, Rania Makboul, Fatma A.M. Badary, Thanaa M.M. Sotouhy Pathophysiology Volume 25, Issue 2, Pages 83-88 (June 2018) DOI: 10.1016/j.pathophys.2018.01.003 Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig 1 Bcl2 immunohistochemical expression. (A): A glomerulus from the normal control kidney tissue showing bcl2 expression in tubules and parietal epithelial cells and no staining within the glomerular tuft (×400). (B and C): Bcl2 immunostaining within mesangial cells in glomeruli of LN (×400). (D): Bcl2 immunostaining in an early crescent in LN (×400). Pathophysiology 2018 25, 83-88DOI: (10.1016/j.pathophys.2018.01.003) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 2 The mean number of intraglomerular bcl2 positive cells in different classes of LN. Pathophysiology 2018 25, 83-88DOI: (10.1016/j.pathophys.2018.01.003) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 3 Bax immunohistochemical expression. (A): A glomerulus from the normal control kidney tissue showing bax expression in tubules and no staining within the glomerular tuft (×400). (B): Bax immunostaining within visceral epithelial cells in a glomerulus of LN (×400). (C): Bax immunostaining within mesangial cells in a glomerulus of LN (×400). (D): Bax immunostaining in a crescent in LN (×400). Pathophysiology 2018 25, 83-88DOI: (10.1016/j.pathophys.2018.01.003) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 4 Correlation between the bax to bcl2 ratio and the degree of glomerular sclerosis. 0 = No glomerular sclerosis. 1 = mild (less than 25% of the glomeruli are sclerosed). 2 = moderate (25–50% of glomeruli are sclerosed). Pathophysiology 2018 25, 83-88DOI: (10.1016/j.pathophys.2018.01.003) Copyright © 2018 Elsevier B.V. Terms and Conditions