Volume 79, Issue 9, Pages (May 2011)

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Presentation transcript:

Volume 79, Issue 9, Pages 929-930 (May 2011) Journal Club Kidney International Volume 79, Issue 9, Pages 929-930 (May 2011) DOI: 10.1038/ki.2011.81 Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure Proposed mechanism for aldosterone-producing adenoma and mendelian aldosteronism. (a) Adrenal glomerulosa cells have a high resting K+ conductance, which produces a highly negative membrane potential. (b) Membrane depolarization by either elevation of extracellular K+ or closure of K+ channels by angiotensin II activates voltage-gated Ca2+ channels, increasing intracellular Ca2+ levels, and this provides signals for increased aldosterone synthesis and for increased cell proliferation. (c) Channels containing KCNJ5 with mutations conduct Na+, resulting in Na+ entry, chronic depolarization, constitutive aldosterone production, and cell proliferation. Kidney International 2011 79, 929-930DOI: (10.1038/ki.2011.81) Copyright © 2011 International Society of Nephrology Terms and Conditions