Trials Update Connie Shiridzinomwa Urology Research Nurse

Recruiting trials Add-Asprin IROC Pre-Empt PRIM

Recruiting Trials Add-aspirin A phase III, double-blind, placebo-controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours. Recruiting areas, gastro, prostate and colorectal Target 30 end of recruitment January 2021 Recruited 24 Recruitment challenges: Uptake decrease following media

Recruiting trials IROC A phase III multicentre randomised controlled trial to compare the efficacy of Robotically Assisted Radical Cystectomy (RARC) and intracorporeal urinary diversion with Open Radical Cystectomy (ORC) in patients with bladder cancer Trust target 15 end of recruitment Nov 2018 Recruited 12 Challenges: Large catchment area network patients not prepared to come back for follow-up visits.

Recruiting Trials Pre-EMPT: The Prostate cancer – Exercise and Metformin Trial (Pre-EMpT) is organised by the National Institute for Health Biomedical Research Centre (Nutrition), which is funded by the National Institute for Health Research and is a partnership between the University Hospitals Bristol NHS Foundation Trust and the University of Bristol. Target 183, end date March 2020 Recruited 6, all in surgery Recruitment challenges: Slow up take, people already on Metformin, difficult pathway for radiotherapy and AS

Recruiting trials PRIM: Prostate Health Index (PHI)- to Refine prostate Imaging by MRI (PRIM): Target 100, end of recruitment August 2019 Recruited from 28 No challenges at present

Trials in follow-up POUT (close date Dec 2021) Boxit (close date Dec 2018) Radicals (close date 2031) Source (follow-up until progression) MASTER (closing date Dec 2019)

Studies in set-up JANSSEN: Randomized, Double-blind, Placebo-controlled, Phase 3 Study of Apalutamide in Subjects with High-risk, Localized or Locally Advanced Prostate Cancer Who are Candidates for Radical Prostatectomy HAARP: (Newcastle) Home Assessment of urinary voiding and storage function before and After Radical Prostatectomy for prostate cancer: setting patient expectations (The HAARP study) Neurosafe : (UCL)   A single blinded, multi‐centre, feasibility study to evaluate the ability to randomise men with prostate cancer into a trial comparing NeuroSAFE Robotic assisted radical prostatectomy (RALP) to standard Robotic assisted radical prostatectomy(RALP).

Studies in set up CamProbe: ( Cambridge)Developing a safer and simple device for local anaesthetic transperineal prostate biopsies Gap 4  Interval: (Movember)difficulties in setting this study up include delivery of the exercise intervention, work is ongoing to try to resolve this.

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