Bitter-Sweet Solution in Taste Transduction Hubert Amrein, Steve Bray  Cell  Volume 112, Issue 3, Pages 283-284 (February 2003) DOI: 10.1016/S0092-8674(03)00077-1

Figure 1 Models of Taste Perception Model A favors a large fraction of broadly tuned taste receptor cells (TRC), where many cells can recognize bitter compounds, sugars, and amino acids and, hence, express multiple receptor types (area outlined with bold line). Moreover, this model favors multiple signaling pathways, even within a taste modality, such as sweet taste (indicated by different fill patterns). Model B proposes that each TRC is dedicated to a single taste quality converging on a common signaling cascade. Circles represent TRC populations expressing one receptor type (sweet = T1R2/T1R3, umami = T1R1/T1R3, bitter = many T2Rs). Cell 2003 112, 283-284DOI: (10.1016/S0092-8674(03)00077-1)