In what ways did surgery change in the years 1845-1945 In what ways did surgery change in the years 1845-1945? 15 mark criteria Introduction (Has surgery changed?) Paragraph 1: Surgery in the mid nineteenth century Paragraph 2: The development of anaesthetics and antiseptics Paragraph 3: The discovery of penicillin (Fleming/Florey and Chain) Paragraph 4: Development of Germ theory Conclusion – Overall, how much have things changed? For the top marks, link all of the developments as you write about them.

DITs Have a look through – I have spent a lot of time marking these so I would like you to have completed them all.

DIT Which of these factors has most affected the development of medicine in 1845-1945? Why? Chance War Government Individuals Technology

Florey and Chain It was the Second World War which finally brought about the successful development of penicillin. In the 1930s two Oxford scientists, Howard Florey and Ernst Chain, became interested in Fleming’s 1929 paper on penicillin. In 1939 they assembled a team of pathologists, chemists and biochemists, and three days after the outbreak of war Florey asked the British government for money to fund the team’s research into penicillin. Howard Florey (left) and Ernst Chain. What factors does this slide highlight? Individuals, governments Do you think this was a good time for Florey to approach the government for money into this kind of research? Why?

The development of penicillin Stage 1:Growing the penicillin This was a combination of the latest freeze-drying technology and some much more traditional equipment: thousands of milk bottles (in which to grow the penicillium mould), milk churns, a dog bath and a hand pump! From this, the team were able to gather a few grams of pure penicillin. Stage 2: Testing penicillin on animals There was enough penicillin to test it on eight mice. They were injected with a deadly bacteria (streptococci). Four of the mice were then given penicillin. 24 hours later the mice which had not been injected with penicillin were dead. Those who had been injected were healthy. Stage 3: The first human trial of penicillin By 1941 the team had enough penicillin to test it on a human. The patient had terrible abscesses which had spread from his mouth to his scalp, eyes, arm and even his lung. He was going to die – there was nothing to lose by trying penicillin. After four days of treatment he was much improved and was sitting up in bed – penicillin worked. However, they did not have enough, and after five days the supply ran out – the patient relapsed and died. Factors: technology, scientific experiment, individuals

Production continues... but not in great quantities! Although this first patient still died, it was clear that penicillin was a powerful drug. Production remained painfully slow, but as new batches were produced, two more patients were successfully treated. In August 1942, Fleming himself used penicillin to successfully treat a friend who had meningitis. But the war was producing thousands of casualties – penicillin needed to be mass produced if lives were to be saved.

Steps to Successful Mass Production June 1941: Florey travels to US to try to get drug companies to develop penicillin – not much interest. December 1941: US enters the war 1942: US government gives $80 million to 4 drug companies to find a way to mass produce penicillin. 1943: Mass production began. Penicillin first used by British army in North Africa. June 1944: Enough penicillin is available to treat all the casualties of D-Day. 1945: US Army using 2 million doses of penicillin a month After WW2: Penicillin made available for civilian use. Communication, war, governments, industry

Questions Where were Florey and Chain from? 2. What were the three stages of development of penicillin? 3. When are what did Fleming himself use penicillin to cure on a friend? 4. What big event made penicillin a priority and in turn mass production?