The Sum of All Browning in FGF21 Therapeutics

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The Sum of All Browning in FGF21 Therapeutics Paul Lee, Michael M. Swarbrick, Jerry R. Greenfield  Cell Metabolism  Volume 21, Issue 6, Pages 795-796 (June 2015) DOI: 10.1016/j.cmet.2015.05.018 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Diagram Illustrating Interplay between Central/Peripheral FGF21 Actions, Thermogenesis, iBAT, and igWAT The efficacy of FGF21 therapeutics is mediated via (1) UCP1-dependent thermogenesis (i.e., igWAT browning + re-browning of whitened iBAT resulting in overall boosting of whole-body BAT function), (2) UCP1-independent thermogenesis (e.g., stimulation of multi-organ mitochondrial biogenesis and PGC-1α enrichment), and (3) central nervous system (CNS) mechanisms. Cell Metabolism 2015 21, 795-796DOI: (10.1016/j.cmet.2015.05.018) Copyright © 2015 Elsevier Inc. Terms and Conditions

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