Sudden Arrhythmic cardiac Deaths (SADS)

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Presentation transcript:

Sudden Arrhythmic cardiac Deaths (SADS)

Overall categories

What is SADS/MNH?

How is SADS diagnosed?

It can happen in maternity unit

….but more often outside hospital

How the SADS cases were identified

The SADS autopsy diagnostic process

Diagnostic catches – pathologists have been reluctant to consider SADS

…and another

Epidemiology of SADS in pregnancy

SADS deaths in relation to time period of pregnancy 2009-14, UK and Ireland

Place of death

Demographics of the women who died of SADS

Other observations

Pathogenesis of SADS in pregnancy

Phenotypes of SADS/MNH – inherited conditions

Maternal deaths from SADS/MNH, UK 2003-14: data from the confidential enquiries

Comparisons

Long QT and pregnancy

SADS related to LQTS – a “first”

Likelihood of identifying an inheritable predisposition to SADS/MNH – data from non-pregnant populations

Final observations from this Enquiry

Final messages