Eos, Goddess of Treg Cell Reprogramming

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Eos, Goddess of Treg Cell Reprogramming Sadiye Amcaoglu Rieder, Ethan M. Shevach  Immunity  Volume 38, Issue 5, Pages 849-850 (May 2013) DOI: 10.1016/j.immuni.2013.05.001 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Downregulation of the Transcription Factor Eos Is Required for Treg Cell Reprogramming into T Helper Cells Vaccination with ovalbumin in incomplete Freund’s adjuvant in the presence of the TLR9 agonist CpG results in IL-6 secretion by activated DCs in the draining lymph nodes. Recognition of MHC-II and self-peptide complexes along with IL-6 signaling results in phosphorylation of STAT-3 and subsequent downregulation of Eos. Reprogrammed Eos-labile Treg cells express proinflammatory cytokines (e.g., IL-2 and IL-17), upregulate CD40L, and license DCs for antigen presentation and CD8+ T cell priming. Immunity 2013 38, 849-850DOI: (10.1016/j.immuni.2013.05.001) Copyright © 2013 Elsevier Inc. Terms and Conditions