Mechanisms of Drug-Induced Allergy

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Presentation transcript:

Mechanisms of Drug-Induced Allergy Benno Schnyder, MD, Werner J. Pichler, MD Mayo Clinic Proceedings Volume 84, Issue 3, Pages 268-272 (March 2009) DOI: 10.4065/84.3.268 Copyright © 2009 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 1 Specific T-cell recognition of drug-carrier compounds (hapten/prohapten concept). Drug/drug-metabolite carrier compounds are presented on antigen-presenting cells (APCs), where T cells with appropriate T-cell receptors (TCRs) recognize them. MHC = major histocompatibility complex. Mayo Clinic Proceedings 2009 84, 268-272DOI: (10.4065/84.3.268) Copyright © 2009 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 2 Stimulation of specific T cells by a native drug (the concept of pharmacological interactions of drugs with immune receptors). Memory T cells (TMEMORY) with a certain sensitization may be stimulated by an interaction of a native drug with the T-cell receptor (TCR), supplemented by the interaction with a fitting major histocompatibility complex (MHC) molecule. APC = antigen-presenting cell. Mayo Clinic Proceedings 2009 84, 268-272DOI: (10.4065/84.3.268) Copyright © 2009 Mayo Foundation for Medical Education and Research Terms and Conditions