Oral and topical boswellic acid attenuates mouse osteoarthritis

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Oral and topical boswellic acid attenuates mouse osteoarthritis Q. Wang, X. Pan, H.H. Wong, C.A. Wagner, L.J. Lahey, W.H. Robinson, J. Sokolove Osteoarthritis and Cartilage Volume 22, Issue 1, Pages 128-132 (January 2014) DOI: 10.1016/j.joca.2013.10.012 Copyright © 2013 Terms and Conditions

Fig. 1 Oral or topical boswellic acid reduces cartilage erosion in a mouse model of OA. Mice were surgically induced to develop OA via DMM, and then treated with vehicle, oral boswellic acid, or boswellic acid ointment for 12 weeks after surgery. (A–F) Representative Safranin-O-stained sections of the medial region of the mouse stifle joints at 12 weeks. Scale bar: low-magnification (top) images, 500 μM; high-magnification (bottom) images, 125 μm. (G) Quantification of cartilage loss in mice treated with vehicle ointment, oral, or topical boswellic acid ointment (n = 8 mice per group). Data are shown as the mean + 95% CI. **P < 0.01 by Student's t-test. Results shown are representative of two independent experiments. Osteoarthritis and Cartilage 2014 22, 128-132DOI: (10.1016/j.joca.2013.10.012) Copyright © 2013 Terms and Conditions

Fig. 2 Boswellic acid inhibits IL-1β and TLR4 induced cytokine production from OA synovium. Mice were surgically induced to develop OA via DMM and treated with topical Boswellic acid ointment or vehicle control (n = 3 mice per treatment group) and at 4 months, OA synovial tissue was microdissected and tissue lysates directly assayed for levels of inflammatory cytokines (A). Alternatively, mice were surgically induced to develop OA and left untreated and at 4 months, OA synovial tissue was microdissected and stimulated with IL-1β (B) or LPS (C, D) with or without Boswellic acid pre-treatment and levels of a panel of inflammatory mediators measured by quantitative PCR or by multiplex immunoassay. All experiments were performed in triplicate. Data are shown as the mean + 95% CI. *P < 0.05, **P < 0.01, ***P < 0.001 by unpaired t-test. LPS, lipopolysaccharide; IL, interleukin; MCP, monocyte chemotactic protein; RANTES, regulated on activation normal T cell expressed and secreted; TNF, tumor necrosis factor; MMP, matrix metalloproteinase; ADAMTs, a disintegrin and metalloproteinase with thrombospondin motifs; VEGF, vascular endothelial growth factor; COX, cyclooxygenase. Osteoarthritis and Cartilage 2014 22, 128-132DOI: (10.1016/j.joca.2013.10.012) Copyright © 2013 Terms and Conditions