Salvatore Romeo, Angelo P. Dei Tos, Pancras C.W. Hogendoorn

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The clinical impact of molecular techniques on diagnostic pathology of soft tissue and bone tumours Salvatore Romeo, Angelo P. Dei Tos, Pancras C.W. Hogendoorn Diagnostic Histopathology Volume 18, Issue 2, Pages 81-85 (February 2012) DOI: 10.1016/j.mpdhp.2011.11.004 Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 1 (a) Low grade myxofibrosarcoma is made up of elongated “bland-looking” spindle cells which may closely simulate perineurioma (HE staining 200× original magnification). (b) Identification of the specific FUS rearrangement and its related transcript as either FUS-CREB3L1 or FUS-BBF2H7 is helpful for the correct diagnosis [Multiplex PCR showed amplified transcript for FUS-CREB3L1 only in the tested tumour (C+16114.2) but neither in the normal tissue (12533/10) nor in the negative control (NTC: water), beta actin is amplified in both the tumour as well as the normal tissue but not in the negative control (NTC: water) (courtesy of M. Campo dell–Orto MSc)]. (c) Positive immunostain for MUC4 may be useful in dubious case (200× original magnification). Diagnostic Histopathology 2012 18, 81-85DOI: (10.1016/j.mpdhp.2011.11.004) Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 2 (a) Fibrous dysplasia is made up of irregularly shaped trabeculae of woven bone embedded in cellular fibrous tissue (200× original magnification) (b) Cellular intramuscular myxoma is made up of bland spindle cells immersed in abundant myxoid matrix (200× original magnification) (c) Both lesions are associated with activating mutation of GNAS1 (courtesy of A.M. Cleton-Jansen MSc, PhD). Diagnostic Histopathology 2012 18, 81-85DOI: (10.1016/j.mpdhp.2011.11.004) Copyright © 2011 Elsevier Ltd Terms and Conditions