Volume 72, Issue 2, Pages (July 2007)

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Volume 72, Issue 2, Pages 219-224 (July 2007) Nephropathy associated with the diffuse infiltrative lymphocytosis syndrome L. Zafrani, P. Coppo, S. Dettwiler, V. Molinier-Frenkel, F. Agbalika, J.-B. Guiard-Schmid, G. Pialoux, Y.-C. Xu-Dubois, E. Rondeau, A. Hertig Kidney International Volume 72, Issue 2, Pages 219-224 (July 2007) DOI: 10.1038/sj.ki.5002207 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Renal biopsy findings. (a) Widespread expansion of the renal interstitium by large sheets of inflammatory cells. (b) The dense cellular interstitial infiltrates are composed of lymphocytes, monocytes and plasma cells. (c) Alteration of the tubules with varying degree of tubulitis and tubular destruction. Kidney International 2007 72, 219-224DOI: (10.1038/sj.ki.5002207) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 2 Characterization of infiltrating cells. By immunohistochemistry, the dense cellular infiltrate is composed of (a) some CD20+ B cells but most are (b) CD3+ (c) CD8+ (clone C8/144b, diluted 1/50, Dako, Trappers, France) T lymphocytes, which have infiltrated tubules. Some of these infiltrating cells express Granzyme B (clone GrB-7, diluted 1/100, Dako), suggesting (d) a cytolytic activity. Kidney International 2007 72, 219-224DOI: (10.1038/sj.ki.5002207) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 3 TCRγ rearrangement analysis. PCR products from a multiplex PCR amplification of the γ chain gene locus on DNA extracted from blood and renal biopsy migrated using denaturing gradient gel electrophoresis (lanes 3 and 4, respectively). As a sensitivity control, DNA from the Jurkat T-cell line was diluted in DNA from normal donors peripheral blood monocytes before PCR (lane 1, 10%; lane 2, 1%). Arrows indicate the two alleles of a weakly dominant T-cell clone detected both in the blood and in the kidney. A faint oligoclonal pattern (above the intensity of lane 2 sensitivity control) is also detected. Kidney International 2007 72, 219-224DOI: (10.1038/sj.ki.5002207) Copyright © 2007 International Society of Nephrology Terms and Conditions