Efficacy of a Russian-backbone live attenuated influenza vaccine among young children in Bangladesh: a randomised, double-blind, placebo-controlled trial

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Presentation transcript:

Efficacy of a Russian-backbone live attenuated influenza vaccine among young children in Bangladesh: a randomised, double-blind, placebo-controlled trial W Abdullah Brooks, MD, K Zaman, PhD, Kristen D C Lewis, PhD, Justin R Ortiz, MD, Doli Goswami, MBBS, Jodi Feser, MPH, Amina Tahia Sharmeen, MBBS, Kamrun Nahar, MBBS, Mustafizur Rahman, PhD, Mohammed Ziaur Rahman, PhD, Burc Barin, PhD, Muhammad Yunus, MBBS, Alicia M Fry, MD, Joseph Bresee, MD, Tasnim Azim, PhD, Prof Kathleen M Neuzil, MD The Lancet Global Health Volume 4, Issue 12, Pages e946-e954 (December 2016) DOI: 10.1016/S2214-109X(16)30200-5 Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 1 Trial profile LAIV=live attenuated influenza vaccine. The Lancet Global Health 2016 4, e946-e954DOI: (10.1016/S2214-109X(16)30200-5) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 2 Influenza circulation in the study area overall and in Kamalapur and Matlab, by type and subtype or lineage, in weeks 9–52 of 2013 (A) The whole study area. (B) Kamalapur. (C) Matlab. Circulating and vaccine B strains were mismatched and, therefore, did not contribute to vaccine efficacy The Lancet Global Health 2016 4, e946-e954DOI: (10.1016/S2214-109X(16)30200-5) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions